Report of the 23rd nationwide follow-up survey of primary liver cancer in Japan (2014-2015)

Hiroko Iijima; Masatoshi Kudo; Shoji Kubo; Masayuki Kurosaki; Michiie Sakamoto; Shuichiro Shiina; Ryosuke Tateishi; Nakashima Osamu; Takumi Fukumoto; Yutaka Matsuyama; Takamichi Murakami; Arata Takahashi; Hiroaki Miyata; Norihiro Kokudo

doi:10.1111/hepr.13953

Report of the 23rd nationwide follow-up survey of primary liver cancer in Japan (2014-2015)

Hepatol Res. 2023 Oct;53(10):895-959. doi: 10.1111/hepr.13953. Epub 2023 Sep 5.

Authors

Hiroko Iijima^{1

2}, Masatoshi Kudo^{1

3}, Shoji Kubo^{1

4}, Masayuki Kurosaki^{1

5}, Michiie Sakamoto^{1

6}, Shuichiro Shiina^{1

7}, Ryosuke Tateishi^{1

8}, Nakashima Osamu^{1

9}, Takumi Fukumoto¹⁰, Yutaka Matsuyama^{1

11}, Takamichi Murakami^{1

12}, Arata Takahashi^{1

13

14}, Hiroaki Miyata^{1

13

14}, Norihiro Kokudo^{1

15}

Affiliations

¹ Follow-up Survey Committee, Japan Liver Cancer Association, Osaka, Japan.
² Department of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
³ Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
⁴ Department of Hepato-Biliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
⁵ Department of Gastroenterology, Musashino Red Cross Hospital, Tokyo, Japan.
⁶ School of Medicine, International University of Health and Welfare, Tokyo, Japan.
⁷ Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
⁸ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁹ Department of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Japan.
¹⁰ Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
¹¹ Department of Biostatistics, School of Public Health, University of Tokyo, Tokyo, Japan.
¹² Department of Diagnostic and Interventional Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
¹³ National Clinical Database, Tokyo, Japan.
¹⁴ Department of Healthcare Quality Assessment, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
¹⁵ National Center for Global Health and Medicine, Tokyo, Japan.

PMID: 37574758
DOI: 10.1111/hepr.13953

Abstract

For the 23rd Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 20 889 newly registered patients and 42 274 previously registered follow-up patients were compiled from 516 institutions over a 2-year period from January 1, 2014 to December 31, 2015. Basic statistics compiled for patients newly registered in the 23rd survey were cause of death, past medical history, clinical diagnosis, imaging diagnosis, treatment-related factors, pathological diagnosis, recurrence status, and autopsy findings. Compared with the previous 22nd survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, had more patients with non-B non-C HCC, had smaller tumor diameter, and was more frequently treated with hepatectomy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma, and combined hepatocellular cholangiocarcinoma (combined HCC and intrahepatic cholangiocarcinoma) by treatment type and background characteristics for patients newly registered between 2004 and 2015 whose final outcome was survival or death. The median overall survival and cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter, Child-Pugh grade, or albumin-bilirubin grade) and by treatment type (hepatectomy, radiofrequency ablation therapy, transcatheter arterial chemoembolization, hepatic arterial infusion chemotherapy, and systemic therapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2015 into five time period groups. The data obtained from this nationwide follow-up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer in the world.

Keywords: Japan Liver Cancer Association; combined hepatocellular cholangiocarcinoma; cumulative survival rate; hepatocellular carcinoma; intrahepatic cholangiocarcinoma; nationwide follow-up survey; nationwide survey.