Overview of Equine Stem Cells: Sources, Practices, and Potential Safety Concerns

Thomas G Koch; Alexander G Kuzma-Hunt; Keith A Russell

doi:10.1016/j.cveq.2023.06.008

Overview of Equine Stem Cells: Sources, Practices, and Potential Safety Concerns

Vet Clin North Am Equine Pract. 2023 Dec;39(3):461-474. doi: 10.1016/j.cveq.2023.06.008. Epub 2023 Aug 11.

Authors

Thomas G Koch¹, Alexander G Kuzma-Hunt², Keith A Russell²

Affiliations

¹ Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada. Electronic address: tkoch@uoguelph.ca.
² Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada.

PMID: 37574382
DOI: 10.1016/j.cveq.2023.06.008

Abstract

Over the past 2 decades, equine veterinarians are turning increasingly to stem cell therapies to repair damaged tissues or to promote healing through modulation of the immune system. Research is ongoing into optimizing practices associated with stem cell product transport, dosage, and administration. Culture-expanded equine mesenchymal stem cell therapies seem safe, even when used allogeneically, but various safety concerns should be considered. Stem cells and cellular reprogramming tools hold great promise for future equine therapies.

Keywords: Clinical applications; Equine; Mesenchymal; Pluripotent; Regenerative medicine; Therapy; Tissue engineering; iPSC.

Publication types

Review

MeSH terms

Animals
Horse Diseases* / therapy
Horses
Mesenchymal Stem Cells*
Stem Cell Transplantation / adverse effects
Stem Cell Transplantation / veterinary