Disulfidptosis: disulfide stress-induced cell death

Xiaoguang Liu; Li Zhuang; Boyi Gan

doi:10.1016/j.tcb.2023.07.009

Disulfidptosis: disulfide stress-induced cell death

Trends Cell Biol. 2024 Apr;34(4):327-337. doi: 10.1016/j.tcb.2023.07.009. Epub 2023 Aug 12.

Authors

Xiaoguang Liu¹, Li Zhuang¹, Boyi Gan²

Affiliations

¹ Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
² Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: bgan@mdanderson.org.

PMID: 37574347
DOI: 10.1016/j.tcb.2023.07.009

Abstract

The cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress-induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development. However, recent studies have uncovered an unexpected role of SLC7A11 in promoting disulfidptosis, a novel form of regulated cell death induced by disulfide stress. In this review, we examine the opposing roles of SLC7A11 in regulating redox homeostasis and cell survival/death, summarize current knowledge on disulfidptosis, and explore its potential in disease treatment. A deeper understanding of disulfidptosis will offer new insights into fundamental cellular homeostasis and facilitate the development of innovative therapies for disease treatment.

Keywords: SLC7A11; cystine; disulfide stress; disulfidptosis; ferroptosis; xCT.

Publication types

Review

MeSH terms

Cell Death
Cell Line, Tumor
Cystine* / metabolism
Disulfides*
Humans
Oxidative Stress

Substances

Disulfides
Cystine