Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement

Yuan Zhang; Waleed A S Aldamarany; Guangming Song; Jie Liu; Sha Liu; Yuanyuan Chen; Wenjing Jiang; Geng Zhong

doi:10.1016/j.ijbiomac.2023.126306

Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement

Int J Biol Macromol. 2023 Aug 12:251:126306. doi: 10.1016/j.ijbiomac.2023.126306. Online ahead of print.

Authors

Yuan Zhang¹, Waleed A S Aldamarany², Guangming Song¹, Jie Liu¹, Sha Liu¹, Yuanyuan Chen¹, Wenjing Jiang¹, Geng Zhong³

Affiliations

¹ College of Food Science, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Southwest University, Chongqing 400715, China.
² College of Food Science, Southwest University, Chongqing 400715, China; Food Science and Technology Department, Faculty of Agriculture, Al-Azhar University (Assiut Branch), Assiut 71524, Egypt.
³ College of Food Science, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Southwest University, Chongqing 400715, China. Electronic address: zhongdg@126.com.

PMID: 37573922
DOI: 10.1016/j.ijbiomac.2023.126306

Abstract

In this study, konjac glucomannan (KGM) and its derivatives were gavaged as dietary fiber supplements, followed by a single dose of antibiotic cocktail (Abx) containing amoxicillin, neomycin, metronidazole and vancomycin in mice. The effects of dietary fiber on the pharmacokinetics and tissue distribution of each antibiotic were investigated. The results showed that the specific effects of KGM and its derivatives on the absorption, distribution, and elimination of certain antibiotics varied and depended on the nature of the fibers and the characteristics of the antibiotics. Explicitly, the ingestion of KGM and its derivatives enhanced the absorption of metronidazole by 1.7 times and hindered that of amoxicillin by nearly 36 % without affecting the absorption of neomycin sulfate and vancomycin. KGM and its derivatives had no effect on the distribution of amoxicillin and metronidazole, but DKGM and KGM hindered the distributions of neomycin sulfate (from 1.25 h to 1.62 h) and vancomycin (from 0.95 h to 1.14 h), respectively. KGM and its derivatives promoted the elimination of amoxicillin by nearly 38 % while prolonging that of metronidazole by >50 %. KOGM boosted the elimination of neomycin sulfate and vancomycin, but KGM differed from DKGM in acting on the elimination of both.

Keywords: Antibiotic; Deacetylated konjac glucomannan; Dietary fiber; Konjac glucomannan; Konjac oligo-glucomannan; Pharmacokinetics.