Oxidative stress affects the beginning of the growth of cancer cells through a variety of routes

Pathol Res Pract. 2023 Sep:249:154664. doi: 10.1016/j.prp.2023.154664. Epub 2023 Jul 1.

Abstract

Oxidative stress is a physiological condition that occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the cell's antioxidant defense system. ROS are highly reactive molecules that can cause damage to cellular structures such as DNA, proteins, and lipids. the regulation of ROS levels and the antioxidant defense system is crucial for cancer prevention and treatment. Strategies to enhance antioxidant defenses or induce oxidative stress selectively in cancer cells are being developed as potential therapeutic approaches. targeting oxidative stress in cancer treatment is an active area of research with several potential therapeutic approaches being investigated. Developing selective and effective therapies that target oxidative stress in cancer cells while sparing normal cells will be crucial for improving cancer treatment outcomes.

Keywords: Cancer; Oxidative stress; Therapeutic approaches.

Publication types

  • Review

MeSH terms

  • Antioxidants* / metabolism
  • Humans
  • Neoplasms* / metabolism
  • Oxidative Stress / physiology
  • Proteins / metabolism
  • Reactive Oxygen Species / metabolism

Substances

  • Reactive Oxygen Species
  • Antioxidants
  • Proteins