Levels, tissue distribution and isomer stereoselectivity of Dechlorane Plus in humans: A critical review

Junsong Bao; Hongmin Ren; Jiali Han; Xinrui Yang; Yingxia Li; Jun Jin

doi:10.1016/j.scitotenv.2023.166156

Levels, tissue distribution and isomer stereoselectivity of Dechlorane Plus in humans: A critical review

Sci Total Environ. 2023 Dec 10:903:166156. doi: 10.1016/j.scitotenv.2023.166156. Epub 2023 Aug 11.

Authors

Junsong Bao¹, Hongmin Ren², Jiali Han³, Xinrui Yang⁴, Yingxia Li⁵, Jun Jin⁶

Affiliations

¹ State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
² Department of Chemical Engineering, Hebei Petroleum University of Technology, 2 Xueyuanlu Street, Shuangqiao District, Chengde 067000, China.
³ College of Life and Environmental Sciences, Minzu University of China, 27 Zhongguancun South Street, Haidian District, Beijing 100081, China.
⁴ Hainan Ecological Environmental Monitoring Center, 98 Baiju Avenue, Haikou 571126, China.
⁵ State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China. Electronic address: yingxia@bnu.edu.cn.
⁶ College of Life and Environmental Sciences, Minzu University of China, 27 Zhongguancun South Street, Haidian District, Beijing 100081, China. Electronic address: junjin3799@126.com.

PMID: 37572901
DOI: 10.1016/j.scitotenv.2023.166156

Abstract

Exposure of human tissues to Dechlorane Plus (DP) has raised public concern because of the multiple health threats it may pose to humans. Therefore, it is important to summarize the main findings of previous studies on DP in human tissues and to provide potential guidance for future studies. In this paper, DP levels in different populations and human tissues worldwide since 2009 were systematically reviewed. DP levels in human tissues of workers in e-waste dismantling sites in Guangdong Province, China (median 190 ng·g^-1 lw in serum) and DP manufacturing plants in Jiangsu Province, China (mean 857 ng·g^-1 lw in whole-blood) are the highest reported worldwide. DP levels in tissues of the general population in recent studies are close to those of residents near e-waste dismantling sites, which should be of concern. DP levels in different human tissues were found to be positively correlated with a pattern of blood > breast milk > adipose tissue. The distribution of DP in different human tissues is mainly lipid-driven and may also be influenced by the interaction of DP with proteins such as human serum albumin. Most of the past studies determined the isomer stereoselectivity of DP in human tissues only by comparing the composition of DP in commercial DP products and human tissues, which lacks evidence of mechanism. Recently, a significantly different affinity of DP isomers for proteins was found, which seems to confirm the isomer selectivity of DP in human tissues. We simulated the binding of DP to human serum albumin and DP to thyroid hormone receptor β by molecular docking and found differences in the binding behavior of syn-DP and anti-DP to the selected proteins. Molecular docking seems to be a feasible approach for future studies to predict and reveal the mechanisms of DP behavior and health effects in human tissues.

Keywords: Dechlorane Plus; Isomer stereoselectivity; Molecular docking; Tissue distribution.

Publication types

Review