Rapid detection of bacteria and antimicrobial resistant genes in intraamniotic infection using nanopore adaptive sampling

Piya Chaemsaithong; Piroon Jenjaroenpun; Pisut Pongchaikul; Arunee Singsaneh; Iyarit Thaipisuttikul; Roberto Romero; Thidathip Wongsurawat

doi:10.1016/j.ajog.2023.08.004

Rapid detection of bacteria and antimicrobial resistant genes in intraamniotic infection using nanopore adaptive sampling

Am J Obstet Gynecol. 2023 Dec;229(6):690-693.e1. doi: 10.1016/j.ajog.2023.08.004. Epub 2023 Aug 10.

Authors

Piya Chaemsaithong¹, Piroon Jenjaroenpun², Pisut Pongchaikul³, Arunee Singsaneh⁴, Iyarit Thaipisuttikul⁵, Roberto Romero⁶, Thidathip Wongsurawat⁷

Affiliations

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
² Division of Medical Bioinformatics, Research Department, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Siriraj Long-Read Lab (Si-LoL), Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR.
³ Chakri Naruebodindra Medical Institute, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Samut Prakarn, Thailand; Integrative Computational BioScience Center, Mahidol University, Nakhon Pathom, Thailand; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
⁴ Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
⁵ Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁶ Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI. Electronic address: romeror@mail.nih.gov.
⁷ Division of Medical Bioinformatics, Research Department, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Siriraj Long-Read Lab (Si-LoL), Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Rd., Siriraj, Bangkok Noi, Bangkok, Thailand 10700; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR. Electronic address: thidathip.won@mahidol.edu.

PMID: 37572835
PMCID: PMC11027119 (available on 2024-12-01)
DOI: 10.1016/j.ajog.2023.08.004

Abstract

Nanopore adaptive sampling to diagnose intraamniotic infection

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amniotic Fluid / microbiology
Anti-Infective Agents*
Bacteria
Chorioamnionitis* / microbiology
Female
Humans
Nanopores*

Substances

Anti-Infective Agents

Grants and funding

Z01 HD002400/ImNIH/Intramural NIH HHS/United States