The risk factors for probable REM sleep behavior disorder: A case-control study

Yaqin Xiang; Xiaoxia Zhou; XiuRong Huang; Xun Zhou; Qian Zeng; Zhou Zhou; Qian Xu; Zhenhua Liu; Qiying Sun; Jieqiong Tan; Xinxiang Yan; Beisha Tang; Xuewei Zhang; Jifeng Guo

doi:10.1016/j.sleep.2023.08.007

The risk factors for probable REM sleep behavior disorder: A case-control study

Sleep Med. 2023 Oct:110:99-105. doi: 10.1016/j.sleep.2023.08.007. Epub 2023 Aug 6.

Authors

Yaqin Xiang¹, Xiaoxia Zhou¹, XiuRong Huang¹, Xun Zhou², Qian Zeng¹, Zhou Zhou¹, Qian Xu¹, Zhenhua Liu¹, Qiying Sun², Jieqiong Tan³, Xinxiang Yan¹, Beisha Tang⁴, Xuewei Zhang⁵, Jifeng Guo⁶

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
³ Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China.
⁴ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Centre for Medical Genetics, Central South University, Hunan, China.
⁵ National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Centre for Medical Genetics, Central South University, Hunan, China; Health Management Center, Xiangya Hospital, Central South University, Hunan, China. Electronic address: zhangxuewei@sklmg.edu.cn.
⁶ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Centre for Medical Genetics, Central South University, Hunan, China; Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Hunan, China. Electronic address: guojifeng2003@163.com.

PMID: 37572576
DOI: 10.1016/j.sleep.2023.08.007

Abstract

Objective: To investigate the risk factors for REM sleep behavior disorder (RBD) in a case-control study.

Methods: Participants with probable RBD (pRBD) were defined using the RBD Questionnaire-Hong Kong (RBDQ-HK). Controls were collected by matching age and sex. Demographic information, lifestyle, comorbidity, prodromal symptoms of Parkinson's disease (PD), and blood biomarkers were assessed. The associations between these factors and pRBD were investigated by logistic regression. Partial correlation analysis was used to assess the association between the severity of RBD and depression.

Results: A total of 278 pRBD participants (age = 58.31 ± 15.82 years) and 556 controls (age = 58.16 ± 15.84 years) were enrolled in this study. Patients with pRBD were more likely to be current alcohol drinkers (OR 1.50, 95% CI 1.0-2.32). Participants with pRBD had a higher Hamilton Depression Rating Scale (HAMD-17) score (OR 1.17, 95% CI 1.11-1.22) than controls and were more likely to report arthritis (OR 1.53, 95% CI 1.08-2.16), constipation (OR 1.93, 95% CI 1.31-2.86), hyposmia (OR 1.71, 95% CI 1.10-2.67), and depression (OR 3.15, 95% CI 2.17-4.58). Higher levels of total cholesterol (OR 1.15, 95% CI 0.99-1.33) and low-density lipoprotein (OR 1.21, 95% CI 0.99-1.47) had borderline associations with pRBD. Additionally, the severity of pRBD was positively related to depression (r = 0.31, P < 0.01).

Conclusions: We determined several risk factors for pRBD in this case-control study. Future studies are needed to understand the mechanism underlying the association between these factors and pRBD.

Keywords: Biomarker; REM sleep behavior disorder; Risk factor; Sleep.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Case-Control Studies
Humans
Life Style
Middle Aged
Parkinson Disease* / complications
REM Sleep Behavior Disorder* / complications
REM Sleep Behavior Disorder* / epidemiology
Risk Factors