Metalated Nucleic Acid Nanostructures

Douglas Zhang; Thomas Hermann

doi:10.1007/978-1-0716-3417-2_5

Metalated Nucleic Acid Nanostructures

Methods Mol Biol. 2023:2709:97-103. doi: 10.1007/978-1-0716-3417-2_5.

Authors

Douglas Zhang¹, Thomas Hermann^{2

3

4}

Affiliations

¹ Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA.
² Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA. tch@ucsd.edu.
³ Center for Drug Discovery Innovation, University of California, San Diego, CA, USA. tch@ucsd.edu.
⁴ Program in Materials Science and Engineering, University of California, San Diego, CA, USA. tch@ucsd.edu.

PMID: 37572274
DOI: 10.1007/978-1-0716-3417-2_5

Abstract

Nucleic acid nanotechnology takes advantage of the self-assembling property of nucleic acids to form a variety of shapes and structures. The incorporation of metal ions into these structures introduces functionality for sensor and molecular electronic applications. Here, we describe a protocol for the incorporation of silver ions into polygonal nanoshapes that self-assemble from RNA and DNA modules.

Keywords: Metalated nanostructures; Nucleic acid nanostructures; RNA-DNA hybrid nanoshapes; Silver-mediated base pairs.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

DNA / chemistry
Ions
Nanostructures* / chemistry
Nanotechnology / methods
Nucleic Acid Conformation
Nucleic Acids* / chemistry

Substances

Nucleic Acids
DNA
Ions