Plant-Based Dietary Fibers and Polysaccharides as Modulators of Gut Microbiota in Intestinal and Lung Inflammation: Current State and Challenges

Nutrients. 2023 Jul 26;15(15):3321. doi: 10.3390/nu15153321.

Abstract

Recent research has underscored the significant role of gut microbiota in managing various diseases, including intestinal and lung inflammation. It is now well established that diet plays a crucial role in shaping the composition of the microbiota, leading to changes in metabolite production. Consequently, dietary interventions have emerged as promising preventive and therapeutic approaches for managing these diseases. Plant-based dietary fibers, particularly polysaccharides and oligosaccharides, have attracted attention as potential therapeutic agents for modulating gut microbiota and alleviating intestinal and lung inflammation. This comprehensive review aims to provide an in-depth overview of the current state of research in this field, emphasizing the challenges and limitations associated with the use of plant-based dietary fibers and polysaccharides in managing intestinal and lung inflammation. By shedding light on existing issues and limitations, this review seeks to stimulate further research and development in this promising area of therapeutic intervention.

Keywords: dietary fibers; gut–lung axis; intestinal inflammation; lung inflammation; phytotherapy; plant polysaccharide; prebiotics.

Publication types

  • Review

Grants and funding

This study was supported by North Medicine and Functional Food Characteristic Subject Project in Heilongjiang Province (No. HLJTSXK-2022-03), the excellent youth project of Heilongjiang Natural Science Foundation (No. YQ2023H001), Basic Research Project of Fundamental Research Business Expenses of Education Department in Heilongjiang Province (No. 2021-KYYWF-0586), Basic Research Project of Fundamental Research Business Expenses of Education Department in Heilongjiang Province (No. 2022-KYYWF-0641), the postdoctoral funded project of Heilongjiang Province (No. LBH-Z22292), the Doctoral Special Research Fund launch project of Jiamusi University (No. JMSUBZ2021-10), The Key Laboratory of New Drug Development and Drug Toxicology Evaluation in Heilongjiang Province (No. kfkt2022-14).