Cryoablation following neoadjuvant tyrosine kinase inhibitor as treatment of a T1a renal clear cell carcinoma in a patient with a solitary kidney

BMJ Case Rep. 2023 Aug 11;16(8):e252800. doi: 10.1136/bcr-2022-252800.

Abstract

The case is presented of a woman in her 60s with renal cell carcinoma in a solitary kidney with normal renal function. Because of the solitary kidney status, the management strategy described in acknowledged guidelines was not possible. The patient was treated with standard first-line tyrosine kinase inhibitor followed by percutaneous CT-guided cryoablation. Before and after the procedure the patient had normal kidney function. The treatment resulted in local cancer control, but a bone metastasis developed in the thoracic part of the spine.

Keywords: Cancer intervention; Interventional radiology; Radiology; Renal intervention; Urological cancer.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Renal Cell* / complications
  • Carcinoma, Renal Cell* / diagnostic imaging
  • Carcinoma, Renal Cell* / drug therapy
  • Cryosurgery* / methods
  • Female
  • Humans
  • Kidney Neoplasms* / complications
  • Kidney Neoplasms* / diagnostic imaging
  • Kidney Neoplasms* / drug therapy
  • Neoadjuvant Therapy
  • Retrospective Studies
  • Solitary Kidney*
  • Treatment Outcome
  • Tyrosine Kinase Inhibitors

Substances

  • Tyrosine Kinase Inhibitors