Risk of New-onset Type 1 Diabetes in Danish Children and Adolescents After SARS-CoV-2 Infection: A Nationwide, Matched Cohort Study

Louise Bering; Anne Vinggaard Christensen; Nina Marie Birk; Lau Caspar Thygesen; Henning Bundgaard; Thomas Benfield; Ulrikka Nygaard; Jesper Johannesen; Susanne Dam Nielsen; Selina Kikkenborg Berg

doi:10.1097/INF.0000000000004063

Risk of New-onset Type 1 Diabetes in Danish Children and Adolescents After SARS-CoV-2 Infection: A Nationwide, Matched Cohort Study

Pediatr Infect Dis J. 2023 Nov 1;42(11):999-1001. doi: 10.1097/INF.0000000000004063. Epub 2023 Aug 3.

Authors

Louise Bering¹, Anne Vinggaard Christensen², Nina Marie Birk^{2

3}, Lau Caspar Thygesen⁴, Henning Bundgaard^{2

5}, Thomas Benfield^{6

7}, Ulrikka Nygaard^{5

8}, Jesper Johannesen^{3

7

9}, Susanne Dam Nielsen^{1

5}, Selina Kikkenborg Berg^{2

5}

Affiliations

¹ From the Department of Infectious Diseases.
² Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
³ Department of Pediatrics and Adolescents, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
⁴ Research Department for Health and Morbidity in the Population, National Institute for Public Health, University of Southern Denmark, Copenhagen, Denmark.
⁵ Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁶ Departement of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
⁷ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
⁸ Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
⁹ Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark.

PMID: 37566892
DOI: 10.1097/INF.0000000000004063

Abstract

We investigated the association between SARS-CoV-2 infection and new-onset type 1 diabetes (T1D) in children and adolescents in a nationwide, matched cohort study. The hazard ratio of new-onset T1D within 6 months after SARS-CoV-2 infection was 1.22 (0.58-2.58). The risk of new-onset T1D in children and adolescents was not significantly increased after SARS-CoV-2 infection.

Trial registration: ClinicalTrials.gov NCT04786353.

Associated data

ClinicalTrials.gov/NCT04786353