A rare case of IgG4-associated disease caused by COVID-19: Case report and literature review

Int J Rheum Dis. 2024 Jan;27(1):e14863. doi: 10.1111/1756-185X.14863. Epub 2023 Aug 11.

Abstract

An increasing number of cases have reported that coronavirus disease 2019 (COVID-19) can lead to immune system dysregulation and induce autoimmune diseases, but the mechanism is unclear. We treated a patient who presented with an unknown fever after infection with the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2023. After excluding the possibility of infection, malignancy, and other connective tissue diseases, we considered the diagnosis of IgG4-related disease in consideration of the patient's pathology and clinical findings. In this article, we summarize our diagnostic experience and summarize the case reports of IgG4-related diseases associated with SARS-CoV-2 infections since the COVID-19 pandemic.

Keywords: COVID-19; IgG-related disease; IgG4; SARS-CoV-2; autoimmunity.

Publication types

  • Review
  • Case Reports

MeSH terms

  • COVID-19* / complications
  • COVID-19* / diagnosis
  • Connective Tissue Diseases*
  • Humans
  • Immunoglobulin G
  • Immunoglobulin G4-Related Disease* / diagnosis
  • Immunoglobulin G4-Related Disease* / drug therapy
  • Pandemics
  • SARS-CoV-2

Substances

  • Immunoglobulin G