Marine algal polysaccharides as future potential constituents against non-alcoholic steatohepatitis

Si-Yuan Lu; Karsoon Tan; Saiyi Zhong; Kit-Leong Cheong

doi:10.1016/j.ijbiomac.2023.126247

Marine algal polysaccharides as future potential constituents against non-alcoholic steatohepatitis

Int J Biol Macromol. 2023 Oct 1:250:126247. doi: 10.1016/j.ijbiomac.2023.126247. Epub 2023 Aug 8.

Authors

Si-Yuan Lu¹, Karsoon Tan², Saiyi Zhong³, Kit-Leong Cheong⁴

Affiliations

¹ College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Ocean University, Zhanjiang, China; Guangdong Provincial Key Laboratory of Marine Biotechnology, Department of Biology, College of Science, Shantou University, Guangdong, China.
² Guangxi Key Laboratory of Beibu Gulf Biodiversity Conservation, Beibu Gulf University, Qinzhou, Guangxi, China. Electronic address: tankarsoon@bbgu.edu.cn.
³ College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Ocean University, Zhanjiang, China. Electronic address: zhongsy@gdou.edu.cn.
⁴ College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Ocean University, Zhanjiang, China; Guangdong Provincial Key Laboratory of Marine Biotechnology, Department of Biology, College of Science, Shantou University, Guangdong, China. Electronic address: klcheong@gdou.edu.cn.

PMID: 37562483
DOI: 10.1016/j.ijbiomac.2023.126247

Abstract

Non-alcoholic steatohepatitis (NASH) is one of the most chronic and incurable liver diseases triggered mainly by an inappropriate diet and hereditary factors which burden liver metabolic stress, and may result in liver fibrosis or even cancer. While the available drugs show adverse side effects. The non-toxic bioactive molecules derived from natural resources, particularly marine algal polysaccharides (MAPs), present significant potential for treating NASH. In this review, we summarized the protective effects of MAPs on NASH from multiple perspectives, including reducing oxidative stress, regulating lipid metabolism, enhancing immune function, preventing fibrosis, and providing cell protection. Furthermore, the mechanisms of MAPs in treating NASH were comprehensively described. Additionally, we highlight the influences of the special structures of MAPs on their bioactive differences. Through this comprehensive review, we aim to further elucidate the molecular mechanisms of MAPs in NASH and inspire insights for deeper research on the functional food and clinical applications of MAPs.

Keywords: Functional food; NASH; Seaweeds.

Publication types

Review