A scoping review of studies exploring physical activity and cognition among persons with cancer

Jennifer Brunet; Sitara Sharma

doi:10.1007/s11764-023-01441-x

A scoping review of studies exploring physical activity and cognition among persons with cancer

J Cancer Surviv. 2023 Aug 10. doi: 10.1007/s11764-023-01441-x. Online ahead of print.

Authors

Jennifer Brunet^{1

2

3}, Sitara Sharma⁴

Affiliations

¹ School of Human Kinetics, University of Ottawa, 125 University (MNT 339), Ottawa, ON, K1N 6N5, Canada. jennifer.brunet@uottawa.ca.
² Institut du savoir Montfort, l'Hôpital Montfort, Ottawa, ON, Canada. jennifer.brunet@uottawa.ca.
³ Cancer Therapeutic Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. jennifer.brunet@uottawa.ca.
⁴ School of Human Kinetics, University of Ottawa, 125 University (MNT 339), Ottawa, ON, K1N 6N5, Canada.

PMID: 37561316
DOI: 10.1007/s11764-023-01441-x

Abstract

Purpose: This scoping review aimed to identify and synthesize published studies on physical activity (PA) and cognition among persons with cancer and elucidate knowledge gaps.

Methods: Articles were identified through electronic and manual searches (02/21 and 03/22) using the following inclusion criteria: (1) empirical, peer-reviewed publication in English, (2) sample comprised persons with cancer, and (3) reported at least one statistical association between PA and cognition. Multiple reviewers independently performed study selection and data extraction, and results were mapped in tabular and narrative form.

Results: Ninety-seven articles were eligible; these were largely published from 2017 to 2022 (54.6%), conducted in high-income countries (96.9%), and presented (quasi-)experimental studies (73.2%). Samples predominantly comprised women with breast cancer (48.5%), and recruitment often occurred post-treatment (63.9%). PA interventions included: aerobic (32.3%), resistance (4.8%), combined aerobic/resistance (38.7%), mind-body (19.4%), or other PA (4.8%). Most (66%) articles reported inconclusive findings; 32% were positive (in support of PA promoting cognition or vice versa), and 2.1% were negative. Diverse samples and studies with long-term follow-up were scarce.

Conclusions: The state of knowledge is insufficient and more rigorous, large-scale studies are required to provide definitive conclusions about the cognitive benefits of PA among persons with cancer.

Implications for cancer survivors: Cancer-related cognitive impairment (CRCI) thwarts quality of life. This review summarizes what is known about the association between PA and cognition among persons with cancer and concludes that the evidence is currently equivocal. Hence, it remains uncertain if PA interventions can reduce CRCI, and large-scale PA intervention trials explicitly designed to promote cognition are greatly needed.

Keywords: Cognitive function; Exercise; Oncology; Review.

Publication types

Review