Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

Nadine G Rouphael; Angela R Branche; David J Diemert; Ann R Falsey; Cecilia Losada; Lindsey R Baden; Sharon E Frey; Jennifer A Whitaker; Susan J Little; Satoshi Kamidani; Emmanuel B Walter; Richard M Novak; Richard Rupp; Lisa A Jackson; Tara M Babu; Angelica C Kottkamp; Anne F Luetkemeyer; Lilly C Immergluck; Rachel M Presti; Martín Bäcker; Patricia L Winokur; Siham M Mahgoub; Paul A Goepfert; Dahlene N Fusco; Robert L Atmar; Christine M Posavad; Antonia Netzl; Derek J Smith; Kalyani Telu; Jinjian Mu; Lisa J McQuarrie; Mat Makowski; Mamodikoe K Makhene; Sonja Crandon; David C Montefiori; Paul C Roberts; John H Beigel; Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

doi:10.1093/infdis/jiad323

Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

J Infect Dis. 2023 Dec 20;228(12):1662-1666. doi: 10.1093/infdis/jiad323.

Authors

Nadine G Rouphael¹, Angela R Branche², David J Diemert³, Ann R Falsey², Cecilia Losada¹, Lindsey R Baden⁴, Sharon E Frey⁵, Jennifer A Whitaker⁶, Susan J Little⁷, Satoshi Kamidani^{8

9}, Emmanuel B Walter¹⁰, Richard M Novak¹¹, Richard Rupp¹², Lisa A Jackson¹³, Tara M Babu¹⁴, Angelica C Kottkamp¹⁵, Anne F Luetkemeyer¹⁶, Lilly C Immergluck¹⁷, Rachel M Presti¹⁸, Martín Bäcker¹⁹, Patricia L Winokur²⁰, Siham M Mahgoub²¹, Paul A Goepfert²², Dahlene N Fusco²³, Robert L Atmar⁶, Christine M Posavad^{24

25}, Antonia Netzl²⁶, Derek J Smith²⁶, Kalyani Telu²⁷, Jinjian Mu²⁷, Lisa J McQuarrie²⁷, Mat Makowski²⁷, Mamodikoe K Makhene²⁸, Sonja Crandon²⁸, David C Montefiori²⁹, Paul C Roberts²⁸, John H Beigel²⁸; Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

Collaborators

Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team:
David J Diemert, Elissa Malkin, Jeffrey M Bethony, Aimee Desrosiers, Marc Siegel, Angela R Branche, Ann R Falsey, Edward Walsh, Patrick Kingsley, Michael Peasley, Nadine G Rouphael, Cecilia Losada, Daniel S Graciaa, Hady Samaha, Paulina A Rebolledo, Zanthia Wiley, Lindsey R Baden, Amy C Sherman, Stephen R Walsh, Alexandra Tong, Rebecca Rooks, Sharon E Frey, Getahun Abate, Zacharoula Oikonomopoulou, Daniel F Hoft, Irene Graham, Jennifer A Whitaker, Hana M El Sahly, Wendy A Keitel, C Mary Healy, Robert L Atmar, Susan J Little, Thomas C S Martin, Nicole Carter, Steven Hendrickx, Evan J Anderson, Christina A Rostad, Satoshi Kamidani, Etza Peters, Emmanuel B Walter, Michael J Smith, M Anthony Moody, Kenneth E Schmader, Richard M Novak, Benjamin G Ladner, Andrea Wendrow, Jessica Herrick, Richard Rupp, Laura Porterfield, Lisa A Jackson, Maya Dunstan, Rebecca Lau, Barbara Carste, Tara M Babu, Anna Wald, Taylor Krause, Kirsten Hauge, Angelica C Kottkamp, Mark J Mulligan, Tamia Davis, Celia Engelson, Vijaya Soma, Anne F Luetkemeyer, Chloe Harris, Azquena Munoz Lopez, Lilly C Immergluck, Erica Johnson, Austin Chan, Rachel M Presti, Jane A O'Halloran, Ryley M Thompson, Martín Bäcker, Andrew B Fleming, Sajumon Joseph, Patricia L Winokur, Jeffery Meier, Jack Stapleton, Siham M Mahgoub, Celia Maxwell, Sarah Shami, Paul A Goepfert, Dahlene N Fusco, Arnaud C Drouin, Florice K Numbi, Kirsten E Lyke, David S Stephens, Kathleen M Neuzil, Monica M Farley, Jeanne Marrazzo, Sidnee Paschal Young, Jeffery Lennox, Robert L Atmar, Linda McNeil, Elizabeth Brown, Christine M Posavad, Megan A Meagher, Julie McElrath, Mike Gale, Kuleni Abebe, Mat Makowski, Heather Hill, Jim Albert, Holly Baughman, Lisa McQuarrie, Kalyani Telu, Jinjian Mu, Lisa J McQuarrie, Teri C Lewis, Lisa A Giebeig, Theresa M Engel, Caleb J Griffith, Wendi L McDonald, Alissa E Burkey, Lisa B Hoopengardner, Jessica E Linton, Nikki L Gettinger, David C Montefiori, Amanda Eaton, Derek J Smith, Antonia Netzl, Samuel H Wilks, Sina Türeli, Mamodikoe Makhene, Mohamed Elsafy, Rhonda Pikaart-Tautges, Janice Arega, Binh Hoang, Dan Curtin, Hyung Koo, Elisa Sindall, Sonja Crandon, Marciela M DeGrace, Diane J Post, Seema U Nayak, Paul C Roberts, John H Beigel

Affiliations

¹ Hope Clinic, Emory University, Decatur, Georgia.
² Vaccine and Treatment Evaluation Unit, University of Rochester, New York.
³ George Washington Vaccine Research Unit, George Washington University, Washington, District of Columbia.
⁴ Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
⁵ Center for Vaccine Development, Saint Louis University, Missouri.
⁶ Department of Molecular Virology and Microbiology and Department of Medicine, Baylor College of Medicine, Houston, Texas.
⁷ Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla.
⁸ Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta.
⁹ Department of Pediatrics, Emory University, Atlanta, Georgia.
¹⁰ Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina.
¹¹ Project WISH, University of Illinois at Chicago, Chicago, Illinois.
¹² Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas.
¹³ Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
¹⁴ Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington.
¹⁵ Vaccine and Treatment Evaluation Unit, Manhattan Research Clinic, New York University Grossman School of Medicine, New York, New York.
¹⁶ Department of Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, California.
¹⁷ Clinical Research Center, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia.
¹⁸ Department of Medicine, Washington University School of Medicine, St Louis, Missouri.
¹⁹ Vaccine and Treatment Evaluation Unit, Long Island Research Clinic, New York University Long Island School of Medicine, Mineola, New York.
²⁰ Department of Medicine, University of Iowa College of Medicine, Iowa City, Iowa.
²¹ Howard University College of Medicine, Howard University Hospital, Washington, District of Columbia.
²² Department of Medicine, University of Alabama at Birmingham, Alabama.
²³ Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
²⁴ Infectious Diseases Clinical Research Consortium (IDCRC) Laboratory Operations Unit, Fred Hutchinson Cancer Center, Seattle, Washington.
²⁵ Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.
²⁶ Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, United Kingdom.
²⁷ The Emmes Company, LLC, Rockville, Maryland.
²⁸ Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
²⁹ Department of Surgery, Duke University, Durham, North Carolina.

PMID: 37561027
PMCID: PMC11032204 (available on 2024-08-10)
DOI: 10.1093/infdis/jiad323

Abstract

We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

Keywords: SARS-CoV-2; vaccine; variant.

Publication types

Randomized Controlled Trial
Research Support, N.I.H., Extramural

MeSH terms

2019-nCoV Vaccine mRNA-1273*
Adult
Clinical Protocols
Humans
RNA, Messenger / genetics
Vaccines, Combined

Substances

Vaccines, Combined
2019-nCoV Vaccine mRNA-1273
RNA, Messenger

Abstract

Publication types

MeSH terms

Substances

Grants and funding