Gold-Catalyzed Intramolecular Hydroarylation and Transfer Hydrogenation of N-Aryl Propargylamines to Construct Tetrahydroquinolines and 5,6-Dihydro-4 H-pyrrolo[3,2,1-ij]quinolines

J Org Chem. 2023 Aug 18;88(16):11945-11953. doi: 10.1021/acs.joc.3c01214. Epub 2023 Aug 10.

Abstract

A novel protocol of gold-catalyzed N-aryl propargylamines to construct tetrahydroquinolines and 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolines in moderate to good yields has been developed through the tandem reactions of intramolecular hydroarylation and transfer hydrogenation. The strategy has the advantages of easy access to raw materials, simple reaction conditions, good substrate compatibility, high efficiency, and excellent regioselectivity.