Feasibility and outcomes after dose reduction of immunochemotherapy in young adults with Burkitt lymphoma and leukemia: results of the BURKIMAB14 trial

Haematologica. 2024 Feb 1;109(2):543-552. doi: 10.3324/haematol.2023.283342.

Abstract

High dose-intensive or infusional intermediate-dose immunochemotherapy is highly effective treatment for Burkitt lymphoma irrespective of human immunodeficiency virus (HIV) infection. However, toxicities of these regimens are relevant, especially in older adults and elderly patients. The prospective multicenter BURKIMAB14 trial included four to six blocks of immunochemotherapy according to stage (localized: 1 and 2 non-bulky; advanced: 2 bulky, 3, 4) and age, with dose reduction in patients >55 years old. Dose-intensity of chemotherapy was reduced in patients ≤55 years old after achieving complete metabolic response (CMR). Their outcomes were compared with those of similar patients included in the former BURKIMAB08 trial, in which there was no dose reduction. CMR was attained in 86 of 107 (80%) patients (17/19 in localized stages and 69/88 in advanced stages). Patients from the BURKIMAB14 trial ≤55 years old showed similar overall survival (OS), fewer infections and cytopenias than patients from the BURKIMAB08 trial. Patients >55 years old had a significantly higher treatment- related mortality despite dose reduction of chemotherapy. With a median follow-up of 3.61 years the 4-year OS probability was 73% (range, 63-81%). Age (≤55 vs. >55 years) and stage (localized vs. advanced) had prognostic significance. No significant differences in OS were observed in HIV-positive versus HIV-negative patients. The results of BURKIMAB14 are similar to those of other dose-intensive immunochemotherapy trials. Age >55 years and advanced stage, but not HIV infection, were associated with poor survival. Dose reduction of chemotherapy in young adults in CMR is safe and does not impact outcomes (clinicaltrials gov. Identifier: NCT05049473).

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Burkitt Lymphoma* / drug therapy
  • Burkitt Lymphoma* / pathology
  • Cyclophosphamide / therapeutic use
  • Doxorubicin / therapeutic use
  • Drug Tapering
  • Feasibility Studies
  • HIV Infections* / drug therapy
  • Humans
  • Leukemia* / drug therapy
  • Middle Aged
  • Prospective Studies
  • Rituximab / therapeutic use
  • Young Adult

Substances

  • Cyclophosphamide
  • Doxorubicin
  • Rituximab

Associated data

  • ClinicalTrials.gov/NCT05049473

Grants and funding

Funding: The research was supported in part by the grant 2021 SGR 00771, AGAUR, Generalitat de Catalunya, Spain.