Editorial: Targeting DNA damage response to enhance antitumor innate immunity in radiotherapy

Victoria Valvo; Emanuele Vitale; Marco Tigano; Rachel Evans; Meredith A Morgan; Qiang Zhang

doi:10.3389/fonc.2023.1257622

Editorial: Targeting DNA damage response to enhance antitumor innate immunity in radiotherapy

Front Oncol. 2023 Jul 25:13:1257622. doi: 10.3389/fonc.2023.1257622. eCollection 2023.

Authors

Victoria Valvo^{1

2}, Emanuele Vitale^{3

4}, Marco Tigano⁴, Rachel Evans^{5

6}, Meredith A Morgan¹, Qiang Zhang¹

Affiliations

¹ Department of Radiation Oncology, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, United States.
² Cancer Biology Program, University of Michigan, Ann Arbor, MI, United States.
³ Laboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
⁴ MitoCare Center, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, United States.
⁵ Richard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, Kings College London, London, United Kingdom.
⁶ Translational Medicine, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.

No abstract available

Keywords: DNA damage response; immunotherapy; innate immunity; radiotherapy; tumor microenvironment.

Publication types

Editorial

Grants and funding

This work is supported by the Radiation Research Unit at the CRUK-City of London Centre Award [C7893/A28990] (RE), Alex’s Lemonade Stand and NIH/NCI grant R01CA240515 (MM), the University of Michigan Chad Carr Pediatric Brain Tumor Center (QZ).