Towards unraveling the origins of eukaryotic nuclear genome organization

Abstract

With 3D genome mapping maturing over the past decade, studies exposed the differences between eukaryotic and prokaryotic genome organization. This raises the question of how the complex eukaryotic genome organization originated. Here, I explore potential pathways to answering this question, guided by our changing understanding of the origins of eukaryotes.

Keywords: Asgard archaea; Hi-C; eukaryogenesis; evolutionary cell biology; genome organization.