Hodgkin Lymphoma-related Inflammatory Modification-displayed Castleman Disease-like Histological Features and Positron Emission Tomography/Computed Tomography Usefulness for the Differential Diagnosis

Intern Med. 2024 Apr 1;63(7):993-998. doi: 10.2169/internalmedicine.2284-23. Epub 2023 Aug 9.

Abstract

Hodgkin lymphoma (HL) and idiopathic multicentric Castleman disease (iMCD) are markedly different conditions. However, in some cases, histological similarities caused by elevated cytokines, including interleukin-6, can lead to a misdiagnosis of HL as Castleman disease (CD). We herein report a patient with HL who had been diagnosed with CD by an expert panel and for whom an additional biopsy was useful for determining the correct diagnosis. Furthermore, we analyzed the positron emission tomography/computed tomography findings at the diagnosis and found that the maximum standardized uptake value was useful for distinguishing HL from iMCD.

Keywords: Castleman disease; Hodgkin lymphoma; PET/CT; SUVmax; interleukin-6.

MeSH terms

  • Castleman Disease* / diagnostic imaging
  • Castleman Disease* / pathology
  • Diagnosis, Differential
  • Fluorodeoxyglucose F18
  • Hodgkin Disease* / diagnostic imaging
  • Hodgkin Disease* / pathology
  • Humans
  • Positron Emission Tomography Computed Tomography / methods
  • Positron-Emission Tomography / methods

Substances

  • Fluorodeoxyglucose F18

Supplementary concepts

  • Multi-centric Castleman's Disease