Cleaning crew: Soluble TREM2 mops up complement

Kathryn M Monroe; Joseph W Lewcock

doi:10.1016/j.immuni.2023.07.012

Cleaning crew: Soluble TREM2 mops up complement

Immunity. 2023 Aug 8;56(8):1701-1703. doi: 10.1016/j.immuni.2023.07.012.

Authors

Kathryn M Monroe¹, Joseph W Lewcock²

Affiliations

¹ Denali Therapeutics Inc., South San Francisco, CA 94080, USA. Electronic address: monroe@dnli.com.
² Denali Therapeutics Inc., South San Francisco, CA 94080, USA.

PMID: 37557076
DOI: 10.1016/j.immuni.2023.07.012

Abstract

Whether soluble TREM2 has a functional role in the central nervous system has been unclear. In this issue of Immunity, Zhong et al. show that soluble TREM2 inhibits aberrant synaptic pruning by sopping up the complement factor C1q to protect neurons and mitigate neurodegeneration.

Publication types

Comment

MeSH terms

Complement C1q
Complement System Proteins
Microglia*
Neurons
Synapses*

Substances

Complement System Proteins
Complement C1q