Magnetic-Nanosensor-Based Virus and Pathogen Detection Strategies before and during COVID-19

Kai Wu; Renata Saha; Diqing Su; Venkatramana D Krishna; Jinming Liu; Maxim C-J Cheeran; Jian-Ping Wang

doi:10.1021/acsanm.0c02048

Magnetic-Nanosensor-Based Virus and Pathogen Detection Strategies before and during COVID-19

ACS Appl Nano Mater. 2020 Sep 22;3(10):9560-9580. doi: 10.1021/acsanm.0c02048. eCollection 2020 Oct 23.

Authors

Kai Wu¹, Renata Saha¹, Diqing Su², Venkatramana D Krishna³, Jinming Liu¹, Maxim C-J Cheeran³, Jian-Ping Wang¹

Affiliations

¹ Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
² Department of Chemical Engineering and Material Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
³ Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota 55108, United States.

PMID: 37556271
DOI: 10.1021/acsanm.0c02048

Abstract

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is a threat to the global healthcare system and economic security. As of July 2020, no specific drugs or vaccines are yet available for COVID-19; a fast and accurate diagnosis for SARS-CoV-2 is essential in slowing the spread of COVID-19 and for efficient implementation of control and containment strategies. Magnetic nanosensing is an emerging topic representing the frontiers of current biosensing and magnetic areas. The past decade has seen rapid growth in applying magnetic tools for biological and biomedical applications. Recent advances in magnetic nanomaterials and nanotechnologies have transformed current diagnostic methods to nanoscale and pushed the detection limit to early-stage disease diagnosis. Herein, this review covers the literature of magnetic nanosensors for virus and pathogen detection before COVID-19. We review popular magnetic nanosensing techniques including magnetoresistance, magnetic particle spectroscopy, and nuclear magnetic resonance. Magnetic point-of-care diagnostic kits are also reviewed aiming at developing plug-and-play diagnostics to manage the SARS-CoV-2 outbreak as well as preventing future epidemics. In addition, other platforms that use magnetic nanomaterials as auxiliary tools for enhanced pathogen and virus detection are also covered. The goal of this review is to inform the researchers of diagnostic and surveillance platforms for SARS-CoV-2 and their performances.

Publication types

Review