The effect of C60 fullerene on the mechanokinetics of muscle gastrocnemius contraction in chronically alcoholized rats

Olexandr Motuziuk; Dmytro Nozdrenko; Svitlana Prylutska; Igor Vareniuk; Kateryna Bogutska; Serhii Braniuk; Olexandr Korotkyi; Yuriy Prylutskyy; Uwe Ritter; Jacek Piosik

doi:10.1016/j.heliyon.2023.e18745

The effect of C₆₀ fullerene on the mechanokinetics of muscle gastrocnemius contraction in chronically alcoholized rats

Heliyon. 2023 Jul 27;9(8):e18745. doi: 10.1016/j.heliyon.2023.e18745. eCollection 2023 Aug.

Authors

Affiliations

¹ Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University, Lutsk, 43025, Ukraine.
² Department of Biophysics and Medical Informatics, ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine.
³ Department of Physiology, Plant Biochemistry and Bioenergetics, Faculty of Plant Protection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine, Kyiv, 03041, Ukraine.
⁴ Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Ilmenau, 98693, Germany.
⁵ Intercollegiate Faculty of Biotechnology, University of Gdansk, 80-307, Gdańsk, Poland.

Abstract

The C₆₀ fullerene effect (oral administration at a dose of 1 mg kg^-1) on the selected biomechanical parameters of muscle gastrocnemius contraction, biochemical indicators of blood and muscle tissue as well as histological changes in rat muscle tissue after chronic alcoholization for 3, 6 and 9 months was studied in detail. Water-soluble C₆₀ fullerenes were shown to reduce the pathological processes development in the muscle apparatus by an average of (35-40)%. In particular, they reduced the time occurrence of fatigue processes in muscle during the long-term development of alcoholic myopathy and inhibited oxidative processes in muscle, thereby preventing its degradation. These findings open up the possibility of using C₆₀ fullerenes as potent antioxidants for the correction of the pathological conditions of the muscle system arising from alcohol intoxication.

Keywords: Biomechanical and biochemical parameters; Histological analysis; m. gastrocnemius; С60 fullerene.