Tumor-derived covalent organic framework nanozymes for targeted chemo-photothermal combination therapy

Shengnan Zhou; Tian Tian; Tao Meng; Jin Wu; Danyou Hu; Qiaobo Liao; Jialu Zhuang; Hua Wang; Guiyang Zhang

doi:10.1016/j.isci.2023.107348

Tumor-derived covalent organic framework nanozymes for targeted chemo-photothermal combination therapy

iScience. 2023 Jul 16;26(8):107348. doi: 10.1016/j.isci.2023.107348. eCollection 2023 Aug 18.

Authors

Shengnan Zhou¹, Tian Tian², Tao Meng¹, Jin Wu¹, Danyou Hu¹, Qiaobo Liao³, Jialu Zhuang², Hua Wang², Guiyang Zhang¹

Affiliations

¹ Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, P.R. China.
² Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
³ School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu 210023, China.

Abstract

Covalent organic frameworks (COFs) have garnered enormous attention in anti-cancer therapy recently. However, the intrinsic drawbacks such as poor biocompatibility and low target-specificity greatly restrain the full clinical implementation of COF. Herein, we report a biomimetic multifunctional COF nanozyme, which consists of AIEgen-based COF (TPE-s COF) with encapsulated gold nanoparticles (Au NPs). The nanozyme was co-cultured with HepG2 cells until the cell membrane was fused with lipophilic TPE-s COF-Au@Cisplatin. By using the cryo-shocking method, we fabricated an inactivated form of the TPE-s COF-Au@Cisplatin nanozyme endocytosed in the HepG2 cell membrane (M@TPE-s COF-Au@Cisplatin), which lost their proliferative ability and pathogenicity. Upon laser irradiation, the M@TPE-s COF-Au@Cisplatin nanozymes cleaved, thereby releasing the TPE-s COF-Au nanozyme and Cisplatin to exert their photothermal and drug therapeutic effect. This work opens a new avenue to the synthesis of tumor-derived fluorescent TPE-s COF-Au nanozymes for highly efficient, synergetic, and targeted chemo-photothermal combination therapy of liver cancer.

Keywords: Chemistry; Materials science; Medicine; Nanomaterials.