Role of TNF-α-induced m6A RNA methylation in diseases: a comprehensive review

Youlin Wang; Jing Liu; Yongchen Wang

doi:10.3389/fcell.2023.1166308

Role of TNF-α-induced m6A RNA methylation in diseases: a comprehensive review

Front Cell Dev Biol. 2023 Jul 24:11:1166308. doi: 10.3389/fcell.2023.1166308. eCollection 2023.

Authors

Youlin Wang¹, Jing Liu¹, Yongchen Wang^{1

2}

Affiliations

¹ Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
² General Practice Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Abstract

Tumor Necrosis Factor-alpha (TNF-α) is ubiquitous in the human body and plays a significant role in various physiological and pathological processes. However, TNF-α-induced diseases remain poorly understood with limited efficacy due to the intricate nature of their mechanisms. N6-methyladenosine (m6A) methylation, a prevalent type of epigenetic modification of mRNA, primarily occurs at the post-transcriptional level and is involved in intranuclear and extranuclear mRNA metabolism. Evidence suggests that m6A methylation participates in TNF-α-induced diseases and signaling pathways associated with TNF-α. This review summarizes the involvement of TNF-α and m6A methylation regulators in various diseases, investigates the impact of m6A methylation on TNF-α-induced diseases, and puts forth potential therapeutic targets for treating TNF-α-induced diseases.

Keywords: N6-methyladenosine (m6A); TNF-α; autoimmune disease; immunity; signaling pathway.

Publication types

Review