Two children with late-onset congenital central hypoventilation syndrome were reported, one of whom was male and had no abnormal manifestations after birth, respiratory failure occurs at the age of 1 year and 6 months. After being hospitalized, he was treated with oxygen inhalation and non-invasive ventilation, but carbon dioxide retention could not be corrected. After one month of tracheal intubation, he was failure to wean from ventilator, so tracheostomy was performed. He needs a ventilator to help breath while sleeping, and can breath autonomously during the day without ventilator. The other case was a female, with no abnormalities after birth. At the age of 11 months, she developed respiratory failure. During sleep, the child needs non-invasive assisted ventilation through a nasal mask, and during the day, she breathed autonomously.Two patients were followed up forever 2 years and their growth and development were normal.
摘要: 报道2例确诊为迟发型先天性中枢性低通气综合征患儿，其中1例为男性，出生后无异常，1岁6个月时出现呼吸衰竭表现，住院后予吸氧和无创辅助通气治疗，CO2潴留不能纠正，气管插管呼吸机通气1个月，未能成功拔管，逐行气管切开术，患儿睡眠时需要呼吸机辅助呼吸，清醒时经气管套管自主呼吸。另1例为女性，出生后无异常，11个月时出现呼吸衰竭表现，患儿睡眠时需要经鼻面罩无创辅助通气，白天自主呼吸，活动正常。2例患儿随访2年后生长发育正常。.
Keywords: central hypoventilation; children; congenital; non-invasive ventilation.
Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.