Enzymatic and Non-Enzymatic Uric Acid Electrochemical Biosensors: A Review

Miao Sun; Chuanjin Cui; Hongshuo Chen; Dengling Wang; Wensi Zhang; Wenjin Guo

doi:10.1002/cplu.202300262

Enzymatic and Non-Enzymatic Uric Acid Electrochemical Biosensors: A Review

Chempluschem. 2023 Sep;88(9):e202300262. doi: 10.1002/cplu.202300262.

Authors

Miao Sun¹, Chuanjin Cui¹, Hongshuo Chen¹, Dengling Wang¹, Wensi Zhang¹, Wenjin Guo¹

Affiliation

¹ North China University of Science and Technology, College of Electrical Engineering, Tangshan, 063210, P. R. China.

PMID: 37551133
DOI: 10.1002/cplu.202300262

Abstract

In recent years, the development of electrochemical biosensors for uric acid has made great achievements. Firstly, uric acid electrochemical biosensors were classified according to their reaction mechanism. Then, the reaction mechanism of the uric acid sensor and the application of nano-modified materials were deeply analyzed from the perspective of non-enzyme and enzymes. In this paper, the catalytic oxidation capacity, enzyme adsorption effect, conductivity, robustness, detection range, and detection limit of uric acid sensors were discussed and compared. Finally, the advantages of acid-sensitive electrochemical biosensors were summarized, and the constructive recommendations were proposed for improving the deficiencies of acid biosensors. The potential for further development in this area was also discussed.

Keywords: biosensors; electrochemical; nanomaterials; uric acid; uricase.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques*
Oxidation-Reduction
Uric Acid*

Substances

Uric Acid