Non-oxidative modified low-density lipoproteins: The underappreciated risk factors for atherosclerosis

Yimeng Zhao; Qian Xu; Naiqi He; Mulin Jiang; Yingzhuo Chen; Zhong Ren; Zhihan Tang; Chunyan Wu; Lushan Liu

doi:10.2174/0929867331666230807154019

Non-oxidative modified low-density lipoproteins: The underappreciated risk factors for atherosclerosis

Curr Med Chem. 2023 Aug 7. doi: 10.2174/0929867331666230807154019. Online ahead of print.

Authors

Yimeng Zhao¹, Qian Xu¹, Naiqi He¹, Mulin Jiang¹, Yingzhuo Chen¹, Zhong Ren¹, Zhihan Tang¹, Chunyan Wu¹, Lushan Liu¹

Affiliation

¹ Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease; The Third Affiliated Hospital, Department of Cardiovascular Medicine, Hengyang Medical College, University of South China, Hengyang 421001, China.

PMID: 37550912
DOI: 10.2174/0929867331666230807154019

Abstract

Atherosclerosis, the pathological basis of most cardiovascular diseases, is a main risk factor causing about 20 million deaths each year worldwide. Oxidized low-density lipoprotein is recognized as the most important and independent risk factor in initiating and promoting atherosclerosis. Numerous antioxidants are extensively used in clinical practice, but they have no significant effect on reducing the morbidity and mortality of cardiovascular diseases. This finding suggests that researchers should pay more attention to the important role of non-oxidative modified low-density lipoprotein in atherosclerosis with a focus on oxidized low-density lipoprotein. This review briefly summarizes several important non-oxidative modified low-density lipoproteins associated with atherosclerosis, introduces the pathways through which these non-oxidative modified low-density lipoproteins induce the development of atherosclerosis in vivo, and discusses the mechanism of atherogenesis induced by these non-oxidative modified low-density lipoproteins. New therapeutic strategies and potential drug targets are provided for the prevention and treatment of atherosclerotic cardiovascular diseases.

Keywords: Atherosclerosis; Carbamylated LDL; Glycated LDL; Nitrated LDL; Non-oxidative modified LDLs.