Progress on the pathological tissue microenvironment barrier-modulated nanomedicine

Han Han; Lei Xing; Bi-Te Chen; Yang Liu; Tian-Jiao Zhou; Yi Wang; Ling-Feng Zhang; Ling Li; Chong-Su Cho; Hu-Lin Jiang

doi:10.1016/j.addr.2023.115051

Progress on the pathological tissue microenvironment barrier-modulated nanomedicine

Adv Drug Deliv Rev. 2023 Sep:200:115051. doi: 10.1016/j.addr.2023.115051. Epub 2023 Aug 6.

Authors

Han Han¹, Lei Xing², Bi-Te Chen¹, Yang Liu¹, Tian-Jiao Zhou¹, Yi Wang¹, Ling-Feng Zhang¹, Ling Li³, Chong-Su Cho⁴, Hu-Lin Jiang⁵

Affiliations

¹ State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
² State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China; College of Pharmacy, Yanbian University, Yanji 133002, China.
³ Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China. Electronic address: lingli@seu.edu.cn.
⁴ Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Korea. Electronic address: chocs@snu.ac.kr.
⁵ State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China; College of Pharmacy, Yanbian University, Yanji 133002, China. Electronic address: Jianghulin3@163.com.

PMID: 37549848
DOI: 10.1016/j.addr.2023.115051

Abstract

Imbalance in the tissue microenvironment is the main obstacle to drug delivery and distribution in the human body. Before penetrating the pathological tissue microenvironment to the target site, therapeutic agents are usually accompanied by three consumption steps: the first step is tissue physical barriers for prevention of their penetration, the second step is inactivation of them by biological molecules, and the third step is a cytoprotective mechanism for preventing them from functioning on specific subcellular organelles. However, recent studies in drug-hindering mainly focus on normal physiological rather than pathological microenvironment, and the repair of damaged physiological barriers is also rarely discussed. Actually, both the modulation of pathological barriers and the repair of damaged physiological barriers are essential in the disease treatment and the homeostasis maintenance. In this review, we present an overview describing the latest advances in the generality of these pathological barriers and barrier-modulated nanomedicine. Overall, this review holds considerable significance for guiding the design of nanomedicine to increase drug efficacy in the future.

Keywords: Biological barriers; Cytoprotective barriers; Drug delivery system; Physiological barriers repair; Tissue physical barriers.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems
Humans
Nanomedicine
Nanoparticles* / therapeutic use
Neoplasms* / drug therapy
Tumor Microenvironment