Neuropeptide substance P: A promising regulator of wound healing in diabetic foot ulcers

Jitao Chen; Penghui Ye; Rifang Gu; Huan Zhu; Wenjie He; Xingrui Mu; Xingqian Wu; Huiwen Pang; Felicity Han; Xuqiang Nie

doi:10.1016/j.bcp.2023.115736

Neuropeptide substance P: A promising regulator of wound healing in diabetic foot ulcers

Biochem Pharmacol. 2023 Sep:215:115736. doi: 10.1016/j.bcp.2023.115736. Epub 2023 Aug 5.

Authors

Jitao Chen¹, Penghui Ye¹, Rifang Gu², Huan Zhu¹, Wenjie He¹, Xingrui Mu¹, Xingqian Wu¹, Huiwen Pang³, Felicity Han³, Xuqiang Nie⁴

Affiliations

¹ College of Pharmacy, Zunyi Medical University, Zunyi 563000, China; Key Lab of the Basic Pharmacology of the Ministry of Education & Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
² University Medical Office, Zunyi Medical University, Zunyi 563000, China.
³ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
⁴ College of Pharmacy, Zunyi Medical University, Zunyi 563000, China; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia; Key Lab of the Basic Pharmacology of the Ministry of Education & Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi 563000, China. Electronic address: niexuqiang@zmu.edu.cn.

PMID: 37549795
DOI: 10.1016/j.bcp.2023.115736

Abstract

In the past, neuropeptide substance P (SP) was predominantly recognized as a neuroinflammatory factor, while its potent healing activity was overlooked. This paper aims to review the regulatory characteristics of neuropeptide SP in both normal and diabetic wound healing. SP actively in the regulation of wound healing-related cells directly and indirectly, exhibiting robust inflammatory properties, promoting cell proliferation and migration and restoring the activity and paracrine ability of skin cells under diabetic conditions. Furthermore, SP not only regulates healing-related cells but also orchestrates the immune environment, thereby presenting unique and promising application prospects in wound intervention. As new SP-based preparations are being explored, SP-related drugs are poised to become an effective therapeutic intervention for diabetic foot ulcers (DFU).

Keywords: Angiogenesis; Diabetic foot ulcers; Fibroblasts; Stem cell therapy; Substance P; Wound healing.

Publication types

Review

MeSH terms

Cell Proliferation
Diabetes Mellitus*
Diabetic Foot* / drug therapy
Humans
Skin
Substance P / pharmacology
Substance P / therapeutic use
Wound Healing

Substances

Substance P