Serum concentrations of BDNF in adolescents with metabolic syndrome: a case-control study between normal - BMI adolescents and adolescents with obesity

Flora Bacopoulou; Nikolaos G Angelopoulos; Stavroula Papadodima; Despoina Apostolaki; Aimilia Mantzou; Eleni Koniari; Vasiliki Efthymiou; Artemis Tsitsika; Dimitrios Vlachakis; Evangelia Charmandari; Charikleia Stefanaki

doi:10.1007/s00431-023-05129-3

Serum concentrations of BDNF in adolescents with metabolic syndrome: a case-control study between normal - BMI adolescents and adolescents with obesity

Eur J Pediatr. 2023 Oct;182(10):4595-4603. doi: 10.1007/s00431-023-05129-3. Epub 2023 Aug 7.

Authors

Affiliations

¹ Center for Adolescent Medicine and UNESCO Chair in Adolescent Health Care, First Department of Pediatrics, Medical School, Aghia Sophia Children's Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece.
² University Research Institute of Maternal and Child Health and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece.
³ Department of Forensic Medicine and Toxicology, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece.
⁴ Unit of Clinical and Translational Research in Endocrinology, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Childrens Hospital, 1 Thivon Street, Goudi, 115 27, Athens, Greece.
⁵ MSc "Strategies of Developmental and Adolescent Health", Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece.
⁶ Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855, Athens, Greece.
⁷ Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 11527, Athens, Greece.
⁸ Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527, Athens, Greece.
⁹ Center for Adolescent Medicine and UNESCO Chair in Adolescent Health Care, First Department of Pediatrics, Medical School, Aghia Sophia Children's Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece. cstefanaki@gmail.com.
¹⁰ University Research Institute of Maternal and Child Health and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece. cstefanaki@gmail.com.
¹¹ First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias Str., Goudi, 11527, Athens, Greece. cstefanaki@gmail.com.

Abstract

Brain-Derived Neurotrophic Factor (BDNF) has been linked to various conditions of the cardiovascular and nervous systems. Scarce data exist about the concentrations of BDNF in children and adolescents in relation with obesity and metabolic syndrome (MetS). The aim of this study was to examine the serum BDNF concentrations in adolescents with metabolic syndrome and according to their body mass index (BMI) status. This was a case-control study, assessing BDNF concentrations between adolescents with MetS (with obesity vs. normal-BMI), in relation to sex, anthropometric, metabolic and endocrine parameters. Participants included male and female adolescents, whose anthropometric and metabolic panel, as well as serum BDNF concentrations were measured. A total of 59 adolescents (obesity: 29; normal-BMI: 30) were included in the study. Increased serum BDNF concentrations were observed in MetS adolescents with obesity when compared with normal-BMI adolescents (p < 0.001). Males exhibited higher concentrations of BDNF than females (p = 0.045). The sample was further divided into four categories by sex and BMI status, with normal-BMI females exhibiting significantly lower BDNF concentrations than females and males with obesity(p = 0.005). In the entire study sample, serum BDNF concentrations correlated positively with BMI z-scores, however, this statistical significance was preserved only in the females of the sample. No statistical difference was observed between males of different BMI z-scores categories. Conclusion: Obesity appeared as a major factor for increased serum BDNF concentrations in adolescents with MetS (vs. normal-BMI), with a higher impact on BDNF concentrations in females than males. What is Known: • The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome in adults but data in adolescents are scarce. What is New: • Obesity (vs. normal BMI) was a major factor for increased serum BDNF in adolescents with metabolic syndrome. • Obesity had a higher impact on BDNF concentrations in females than males with metabolic syndrome.

Keywords: Adolescents; BDNF; Brain derived neurotrophic factor; Metabolic syndrome; Obesity.

MeSH terms

Adolescent
Adult
Body Mass Index
Brain-Derived Neurotrophic Factor
Case-Control Studies
Child
Female
Humans
Male
Metabolic Syndrome*
Pediatric Obesity* / complications

Substances

Brain-Derived Neurotrophic Factor
BDNF protein, human