Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

Bowen Zha; Yuxi Luo; Muladili Kamili; Xiaqin Zha

doi:10.3389/fonc.2023.1193665

Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

Front Oncol. 2023 Jul 20:13:1193665. doi: 10.3389/fonc.2023.1193665. eCollection 2023.

Authors

Bowen Zha¹, Yuxi Luo², Muladili Kamili¹, Xiaqin Zha³

Affiliations

¹ The Sixth Clinical Medical College, Capital Medical University, Beijing, China.
² The First Clinical Medical College, Capital Medical University, Beijing, China.
³ Department of Blood Purification, University Affiliated Second Hospital, Nanchang, China.

Abstract

Aim: Provide an overview and a systematic evaluation of the evidence quality on the association between non-coding RNAs (ncRNAs) and prognosis value for gastrointestinal cancers (GICs).

Methods: We searched the literature from three electronic databases: Pubmed, Embase, and Web of science, then carefully screened and extracted the primary information and results from the included articles. We use A measurable systematic review and meta-analysis evaluation tool (AMSTAR2) to evaluate the quality of methodology and then use the Grading of Recommendations Assessment 2, Development and Evaluation guideline (GRADE) make sure the reliability of the meta-analysis.

Results: Overall, 182 meta-analyses from 58 studies were included in this study. Most of these studies are of low or very low quality. Using the scoring tool, we found that only two meta-analyses were rated as high reliability, and 17 meta-analyses were rated as medium reliability.

Conclusions: Although ncRNA has good prognostic value in some studies, only a tiny amount of evidence is highly credible at present. More research is needed in the future.

Prospero registration number: CRD42022382296.

Keywords: gastrointestinal cancers; miRNA; ncRNA; prognosis; umbrella review.