Single-cell characterization of tumor evolution from precursor diseases

Jiling Feng; Yu Zeng; Shengli Li

doi:10.1016/j.trecan.2023.07.012

Single-cell characterization of tumor evolution from precursor diseases

Trends Cancer. 2023 Oct;9(10):775-776. doi: 10.1016/j.trecan.2023.07.012. Epub 2023 Aug 5.

Authors

Jiling Feng¹, Yu Zeng¹, Shengli Li²

Affiliations

¹ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
² Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: shengli.li@sjtu.edu.cn.

PMID: 37544795
DOI: 10.1016/j.trecan.2023.07.012

Abstract

Elucidating the characteristics of precursor diseases is important to the understanding of malignant transformation during tumor progression. In a recent study, Dang et al. characterized the cellular and molecular evolution from precursor conditions to multiple myeloma (MM) by integrating single-cell RNA sequencing (scRNA-seq) and B cell-receptor sequencing (scBCR-seq).

Keywords: multiple myeloma; precursor disease; single-cell sequencing; tumor evolution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Evolution, Molecular
Humans
Multiple Myeloma* / genetics
Receptors, Antigen, B-Cell

Substances

Receptors, Antigen, B-Cell