Progress in construction and release of natural polysaccharide-platinum nanomedicines: A review

Pengge Wang; Yunxia Yang; Haoyu Wen; Dongqing Li; Hongmei Zhang; Yanqing Wang

doi:10.1016/j.ijbiomac.2023.126143

Progress in construction and release of natural polysaccharide-platinum nanomedicines: A review

Int J Biol Macromol. 2023 Oct 1:250:126143. doi: 10.1016/j.ijbiomac.2023.126143. Epub 2023 Aug 6.

Authors

Pengge Wang¹, Yunxia Yang², Haoyu Wen³, Dongqing Li³, Hongmei Zhang³, Yanqing Wang⁴

Affiliations

¹ School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China; College of Biological and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing City, Jiangsu Province 211816, China.
² School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China; Jiangsu Province Engineering Research Center of Agricultural Breeding Pollution Control and Resource, Yancheng Teachers University, Yancheng 224007, China; Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Yancheng 224007, China. Electronic address: yangyx01@yctu.edu.cn.
³ School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China.
⁴ School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China. Electronic address: wyqing76@126.com.

PMID: 37544564
DOI: 10.1016/j.ijbiomac.2023.126143

Abstract

Natural polysaccharides are natural biomaterials that have become candidate materials for nano-drug delivery systems due to their excellent biodegradability and biocompatibility. Platinum (Pt) drugs have been widely used in the clinical therapy for various solid tumors. However, their extensive systemic toxicity and the drug resistance acquired by cancer cells limit the applications of platinum drugs. Modern nanobiotechnology provides the possibility for targeted delivery of platinum drugs to the tumor site, thereby minimizing toxicity and optimizing the efficacies of the drugs. In recent years, numerous natural polysaccharide-platinum nanomedicine delivery carriers have been developed, such as nanomicelles, nanospheres, nanogels, etc. Herein, we provide an overview on the construction and drug release of natural polysaccharide-Pt nanomedicines in recent years. Current challenges and future prospectives in this field are also put forward. In general, combining with irradiation and tumor microenvironment provides a significant research direction for the construction of natural polysaccharide-platinum nanomedicines and the release of responsive drugs in the future.

Keywords: Nanomedicine; Natural polysaccharides; Platinum.

Publication types

Review