Metal-phenolic capsules with ROS scavenging reshape the oxidative microenvironment of atherosclerosis

Aiai Zhang; Kaijing Liu; Xiaoyu Liang; Huiyang Li; Xue Fu; Ni Zhu; Fangjiang Li; Jing Yang

doi:10.1016/j.nano.2023.102700

Metal-phenolic capsules with ROS scavenging reshape the oxidative microenvironment of atherosclerosis

Nanomedicine. 2023 Sep:53:102700. doi: 10.1016/j.nano.2023.102700. Epub 2023 Aug 5.

Authors

Aiai Zhang¹, Kaijing Liu², Xiaoyu Liang², Huiyang Li², Xue Fu², Ni Zhu², Fangjiang Li³, Jing Yang⁴

Affiliations

¹ Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China; The First Affiliated Hospital of Hebei North university, No.12, Changqing Road, Qiaoxi District, Zhangjiakou City, Hebei 075061, China.
² Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.
³ The First Affiliated Hospital of Hebei North university, No.12, Changqing Road, Qiaoxi District, Zhangjiakou City, Hebei 075061, China.
⁴ Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China; Tianjin Medical Health Research Institute, Tianjin 300192, China. Electronic address: yangjing37@hotmail.com.

PMID: 37544347
DOI: 10.1016/j.nano.2023.102700

Abstract

Arterial injury makes the tissue in a state of high oxidative stress. At the same time, abnormal lipid metabolism can further lead to bleeding and thrombosis. Therefore, the anti-inflammatory and anti-oxidant polyphenol, EGCG was organically complexed with Fe³⁺ to form a metal-phenolic framework carrier. And the antihyperlipidemic drug, atorvastatin (ATV) was loaded into the carrier to enhance the bioavailability, and simultaneously alleviate the oxidative stress of the inflammatory site and abnormal lipid metabolism. The results confirmed that the obtained material EGCG-Fe-ATV had good biocompatibility and biosafety effect. In addition, EGCG-Fe-ATV showed outstanding anti-inflammatory, anti-oxidant and lipid-lowering properties. These therapeutic outcomes of EGCG-Fe-ATV were achieved by reducing systemic and local oxidative stress and inflammation, alleviating inflammatory cell infiltration in plaques, and modulating lipid synthesis and transferase to alter cholesterol transport. In conclusion, the combination of metal-phenolic capsules with ATV provides a new strategy for reshaping the oxidative microenvironment of atherosclerosis.

Keywords: Anti-inflammation; Anti-oxidant; Atherosclerosis; Metal-phenolic framework; ROS scavenging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / pharmacology
Antioxidants* / pharmacology
Atherosclerosis* / drug therapy
Atorvastatin / pharmacology
Atorvastatin / therapeutic use
Capsules
Humans
Oxidative Stress
Reactive Oxygen Species / metabolism

Substances

Antioxidants
Reactive Oxygen Species
Capsules
Atorvastatin
Anti-Inflammatory Agents