Evaluation of the Relationship Between Diabetic Macular Edema and Renal Function in a Latino Population

José M Torres-Arellano; Andrea Tornero-Jimenez; Alejandra Sánchez-Ríos; Oscar Olvera-Montaño; Patricia Muñoz-Villegas

doi:10.1007/s40123-023-00787-w

Evaluation of the Relationship Between Diabetic Macular Edema and Renal Function in a Latino Population

Ophthalmol Ther. 2023 Oct;12(5):2745-2755. doi: 10.1007/s40123-023-00787-w. Epub 2023 Aug 6.

Authors

José M Torres-Arellano¹, Andrea Tornero-Jimenez^{1

2}, Alejandra Sánchez-Ríos¹, Oscar Olvera-Montaño¹, Patricia Muñoz-Villegas^{3

4}

Affiliations

¹ Regional Medical Affairs Department, Laboratorios Sophia, S.A. de C.V., Paseo del Norte 5255, Guadalajara Technology Park, 45010, Zapopan, JAL, Mexico.
² Instituto de Investigación en Oftalmología y Ciencias Visuales, CUCS, University of Guadalajara, Sierra Mojada 950, 44340, Guadalajara, JAL, Mexico.
³ Regional Medical Affairs Department, Laboratorios Sophia, S.A. de C.V., Paseo del Norte 5255, Guadalajara Technology Park, 45010, Zapopan, JAL, Mexico. patricia.munoz@sophia.com.mx.
⁴ Centro de Investigación en Matemáticas (CIMAT), Unidad Aguascalientes, Aguascalientes, Mexico. patricia.munoz@sophia.com.mx.

Abstract

Introduction: Diabetic macular edema (DME) is one of the leading causes of vision impairment. The relationship between DME and estimated glomerular filtration rate (eGFR) has not been clearly evaluated in Hispanic or Latino populations. The objective of this study was to evaluate the eGFR in a Latino population with DME.

Methods: A cross-sectional, observational, and descriptive study was carried out on the basis of a multicenter phase III clinical trial.

Results: A total of 82 subjects diagnosed with DME (36 women and 46 men) were included in the study. The mean age was 61.93 ± 6.71 years. Mean values of the blood chemistry parameters glycated hemoglobin and eGFR were 7.20 ± 0.95% and 74.42 ± 26.82 mL/min/1.73 m², respectively. The time elapsed since diagnosis of diabetes mellitus was 15.30 ± 7.35 years, while the duration of DME was 1.41 ± 1.75 years. Mean values for central macular thickness (CMT) and total macular volume (TMV) were 440.99 ± 132.22 µm and 11.97 ± 2.11 mm³, respectively. DME duration had a negative correlation with TMV (Rho - 0.26, p < 0.05) and a positive correlation with mean arterial pressure (Rho 0.26, p < 0.05). CMT was correlated with TMV (Rho 0.43, p < 0.0001) and visual acuity (Rho 0.26, p < 0.05). No significant correlations were observed between eGFR and CMT, TMV, or any demographic variable (p > 0.05). Chronic kidney disease (CKD) was associated with hypertension (OR 9.32, p = 0.035), elevated intraocular pressure (IOP) (OR 0.03, p = 0.011), and advanced age (OR 0.45, p = 0.011). CMT was significantly associated with TMV (β = 27.69, p < 0.0001).

Conclusions: We did not find a correlation between eGFR and DME. Our findings suggest that the presence of hypertension is associated with a decrease in the GFR < 60 mL/min/1.73 m², and CKD may be associated with advanced age and elevated IOP which may increase the risk for the development of glaucoma.

Trial registration: NCT05217680 (clinicaltrials.gov).

Keywords: Central macular thickness; Diabetes mellitus; Diabetic macular edema; Glomerular filtration rate; Total macular volume.

Associated data

ClinicalTrials.gov/NCT05217680