Recent advances in fluorescent probes for dual-detecting ONOO- and analytes

Minglu Li; Peng Lei; Shaomin Shuang; Chuan Dong; Liyun Zhang

doi:10.1016/j.saa.2023.123179

Recent advances in fluorescent probes for dual-detecting ONOO^- and analytes

Spectrochim Acta A Mol Biomol Spectrosc. 2023 Dec 15:303:123179. doi: 10.1016/j.saa.2023.123179. Epub 2023 Jul 21.

Authors

Minglu Li¹, Peng Lei², Shaomin Shuang², Chuan Dong², Liyun Zhang³

Affiliations

¹ Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Tongji Shanxi Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China.
² College of Chemistry and Chemical Engineering & Institute of Environmental Science, Shanxi University, Taiyuan, China.
³ Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Tongji Shanxi Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China. Electronic address: 1315710223@qq.com.

PMID: 37542874
DOI: 10.1016/j.saa.2023.123179

Abstract

Although peroxynitrite (ONOO^-) plays an essential role in cellular redox homeostasis, its excess ONOO^- will affect the normal physiological function of cells. Therefore, real-time monitoring of changes in local ONOO^- will contribute to further revealing the biological functions. Reliable and accurate detection of biogenic ONOO^- will definitely benefit for disentangling its complex functions in living systems. In the past few years, more fluorescent probes have been developed to help understand and reveal cellular ONOO^- changes. However, there has been no comprehensive and critical review of multifunctional fluorescent probes for cellular ONOO^- and other analytes. To highlight the recent advances, this review first summarized the recent progress of multifunctional fluorescent probes since 2018, focusing on molecular structures, response mechanisms, optical properties, and biological imaging in the detection and imaging of cellular ONOO^- and analytes. We classified and discussed in detail the limitations of existing multifunctional probes, and proposed new ideas to overcome these limitations. Finally, the challenges and future development trends of ONOO^- fluorescence probes were discussed. We hoped this review will provide new research directions for developing of multifunctional fluorescent probes and contribute to the early diagnosis and treatment of diseases.

Keywords: Fluorescent probes; Multifunctional; ONOO–.

Publication types

Review

MeSH terms

Fluorescent Dyes* / chemistry
Molecular Structure
Optical Imaging
Peroxynitrous Acid*

Substances

Fluorescent Dyes
Peroxynitrous Acid