The mechanisms, functions and clinical applications of miR-542-3p in human cancers

Shadia Hamoud Alshahrani; Nodir Rakhimov; Jitendra Gupta; Zahraa F Hassan; Ali Alsalamy; Ebraheem Abdu Musad Saleh; Hashem O Alsaab; Firas Kanawy Al-Aboudy; Ahmed Radhi Alawadi; Yasser Fakri Mustafa

doi:10.1016/j.prp.2023.154724

The mechanisms, functions and clinical applications of miR-542-3p in human cancers

Pathol Res Pract. 2023 Aug:248:154724. doi: 10.1016/j.prp.2023.154724. Epub 2023 Jul 27.

Affiliations

¹ Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia.
² Head of the Department of Oncology, Samarkand State Medical University, Amir Temur street 18, Samarkand, Uzbekistan; Department of Scientific Affairs, Tashkent State Dental Institute, Makhtumkuli 103, Tashkent, Uzbekistan.
³ Institute of Pharmaceutical Research, GLA University, Mathura Pin Code 281406, U. P., India. Electronic address: smartjitu79@gmail.com.
⁴ College of Dentistry, Al-Ayen University, Thi-Qar, Iraq.
⁵ Department of Computer Technical engineering, College of Information Technology Imam Ja'afarAl-Sadiq University Al-Muthanna, Iraq.
⁶ Department of Chemistry, Prince Sattam Bin Abdulaziz University, Wadi Al-Dawasir 11991, Saudi Arabia.
⁷ Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi Arabia.
⁸ Department of Nursing, Altoosi University College, Najaf, Iraq.
⁹ Medical Analysis Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.

PMID: 37542861
DOI: 10.1016/j.prp.2023.154724

Abstract

MicroRNAs, as a major type of noncoding RNAs, have crucial roles in various functions during development. Available data have shown that miR-542-3p decreased in various types of cancers. MiR-542-3p is engaged in various cancer-related behaviors like glycolysis, metastasis, epithelial-to-mesenchymal transition (EMT), cell cycle, apoptosis, and proliferation via targeting at least 18 genes and some important signaling pathways like Wnt/β-catenin, Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and Janus kinase 2 (JAK2) signaling, and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling. Current studies have proposed that the level of miR-542-3p could be modulated by several upstream regulators like transcription factors, long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). In addition, the level of miR-542-3p or its related lncRNAs/circRNAs are correlated with poor prognosis and clinicopathological features of cancer-affected patients. Here, we have discussed the biogenesis, function, and regulation of miR-542-3p as well as its aberrant expression in various types of neoplastic cells. Moreover, we have discussed the prognostic value of miR-542-3p in cancer. Finally, we have added the underlying molecular mechanism of miR-542-3p in cancer pathogenesis.

Keywords: Cancer; Prognosis; miR-542-3p; microRNA.

Publication types

Review