Protein kinase C: A potential therapeutic target for endothelial dysfunction in diabetes

Qian Xiao; Dan Wang; Danyang Li; Jing Huang; Feifei Ma; Haocheng Zhang; Yingda Sheng; Caimei Zhang; Xiaoqin Ha

doi:10.1016/j.jdiacomp.2023.108565

Protein kinase C: A potential therapeutic target for endothelial dysfunction in diabetes

J Diabetes Complications. 2023 Sep;37(9):108565. doi: 10.1016/j.jdiacomp.2023.108565. Epub 2023 Jul 28.

Authors

Qian Xiao¹, Dan Wang¹, Danyang Li², Jing Huang¹, Feifei Ma³, Haocheng Zhang⁴, Yingda Sheng¹, Caimei Zhang¹, Xiaoqin Ha⁵

Affiliations

¹ Department of Laboratory, Ninth Forty Hospital of the Chinese People's Liberation Army Joint Security Force, Lanzhou 730050, Gansu, China; School of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China.
² School of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China.
³ Department of Laboratory, Ninth Forty Hospital of the Chinese People's Liberation Army Joint Security Force, Lanzhou 730050, Gansu, China; College of Veterinary Medicine, Gansu Agriculture University, Lanzhou 730070, Gansu, China.
⁴ Department of Laboratory, Ninth Forty Hospital of the Chinese People's Liberation Army Joint Security Force, Lanzhou 730050, Gansu, China; The Second School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
⁵ Department of Laboratory, Ninth Forty Hospital of the Chinese People's Liberation Army Joint Security Force, Lanzhou 730050, Gansu, China; School of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China. Electronic address: 3394919226@qq.com.

PMID: 37540984
DOI: 10.1016/j.jdiacomp.2023.108565

Abstract

Protein kinase C (PKC) is a family of serine/threonine protein kinases that play an important role in many organs and systems and whose activation contributes significantly to endothelial dysfunction in diabetes. The increase in diacylglycerol (DAG) under high glucose conditions mediates PKC activation and synthesis, which stimulates oxidative stress and inflammation, resulting in impaired endothelial cell function. This article reviews the contribution of PKC to the development of diabetes-related endothelial dysfunction and summarizes the drugs that inhibit PKC activation, with the aim of exploring therapeutic modalities that may alleviate endothelial dysfunction in diabetic patients.

Keywords: Diabetes mellitus; Endothelial cell; Inflammation; Oxidative stress; Protein kinase C.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus*
Humans
Oxidative Stress
Protein Kinase C / metabolism
Signal Transduction
Vascular Diseases*

Substances

Protein Kinase C