Dramatic efficacy of cannabidiol on refractory chronic pain in an adolescent with sickle cell disease

Lara Mayrand; Anne-Laure Tarbé de Saint Hardouin; Thiago Trovati Maciel; Rachel Rignault-Bricard; Melissa Taylor; Joséphine Brice; Mariane de Montalembert; Olivier Hermine; Céline Greco; Slimane Allali

doi:10.1002/ajh.27049

Dramatic efficacy of cannabidiol on refractory chronic pain in an adolescent with sickle cell disease

Am J Hematol. 2023 Nov;98(11):E295-E297. doi: 10.1002/ajh.27049. Epub 2023 Aug 4.

Authors

Lara Mayrand^{1

2

3}, Anne-Laure Tarbé de Saint Hardouin³, Thiago Trovati Maciel^{1

4}, Rachel Rignault-Bricard^{1

4}, Melissa Taylor^{2

4}, Joséphine Brice^{2

4}, Mariane de Montalembert^{2

4}, Olivier Hermine^{1

4

5

6}, Céline Greco^{1

3}, Slimane Allali^{1

2

4}

Affiliations

¹ Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163, Université Paris Cité, Paris, France.
² Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
³ Department of Pain and Palliative Care Unit, Necker-Enfants Malades Hospital, AP-HP, Université Paris Cité, Paris, France.
⁴ Laboratory of Excellence GR-Ex, Paris, France.
⁵ Department of Hematology, Necker-Enfants Malades Hospital, AP-HP, Université Paris Cité, Paris, France.
⁶ Reference Center for Mastocytosis, Necker-Enfants Malades Hospital, AP-HP, Paris, France.

PMID: 37540761
DOI: 10.1002/ajh.27049

Abstract

Here, we report a dramatic efficacy of cannabidiol in an adolescent with SCD suffering from chronic pain refractory to other analgesics, with complete regression of chronic pain and rapid plasma histamine level normalization after treatment.

Publication types

Letter