A water-soluble fluorescent organic nano-photosensitizer for the ratiometric detection of mitochondrial G-quadruplexes with photodynamic therapy potential

Qing-Yu Ma; Xiang Li; Wei Zhou; Xia-Fen Li; Yi-Chen Liu; Gai-Li Feng; Hongwei Tan; Yuan Zhang; Guo-Wen Xing

doi:10.1039/d3cc02788k

A water-soluble fluorescent organic nano-photosensitizer for the ratiometric detection of mitochondrial G-quadruplexes with photodynamic therapy potential

Chem Commun (Camb). 2023 Aug 22;59(68):10287-10290. doi: 10.1039/d3cc02788k.

Authors

Qing-Yu Ma¹, Xiang Li¹, Wei Zhou¹, Xia-Fen Li¹, Yi-Chen Liu¹, Gai-Li Feng¹, Hongwei Tan¹, Yuan Zhang^{1

2}, Guo-Wen Xing¹

Affiliations

¹ College of Chemistry, Beijing Normal University, Beijing, 100875, China. yuanzhang@bnu.edu.cn.
² Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing, 100875, China.

PMID: 37539814
DOI: 10.1039/d3cc02788k

Abstract

We report a water-soluble AIEgen (TPAL) that can self-assemble into fluorescent organic nanoparticles for the ratiometric detection of mitochondrial DNA (mtDNA) parallel G-quadruplexes (G4s) with high selectivity, a low detection limit and photodynamic therapy (PDT) potential.

MeSH terms

Coloring Agents
Fluorescent Dyes
G-Quadruplexes*
Photochemotherapy*
Photosensitizing Agents / pharmacology
Photosensitizing Agents / therapeutic use
Water

Substances

Photosensitizing Agents
Water
Coloring Agents
Fluorescent Dyes