Keeping IPMNs in Check: A Novel Role for the Transcription Factor NKX6-2 in Preserving an Indolent Cell Identity in Pancreatic Cystic Lesions

Cancer Discov. 2023 Aug 4;13(8):1768-1770. doi: 10.1158/2159-8290.CD-23-0590.

Abstract

In this issue of Cancer Discovery, Sans and colleagues identify the transcription factor NKX6-2 as a principal element in maintaining the low-grade gastric cell phenotype of intraductal papillary mucinous neoplasms (IPMN) in the pancreas. Their discoveries in patient cohorts and dissection in animal models provide a novel molecular understanding underpinning IPMN differentiation, with implications for risk stratification and therapeutic intervention in pancreatic cancer. See related article by Sans et al., p. 1844 (7).

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Carcinoma, Pancreatic Ductal* / genetics
  • Carcinoma, Pancreatic Ductal* / pathology
  • Cell Differentiation
  • Pancreas / pathology
  • Pancreatic Cyst* / genetics
  • Pancreatic Intraductal Neoplasms*
  • Pancreatic Neoplasms* / genetics
  • Pancreatic Neoplasms* / pathology
  • Transcription Factors / genetics
  • Transcriptome

Substances

  • Transcription Factors