Dexamethasone for delayed edema after intracerebral hemorrhage： To be or not to be?

Yongqing Ye; Jin Xu; Yuhan Han

doi:10.1016/j.heliyon.2023.e17621

Dexamethasone for delayed edema after intracerebral hemorrhage： To be or not to be?

Heliyon. 2023 Jun 28;9(7):e17621. doi: 10.1016/j.heliyon.2023.e17621. eCollection 2023 Jul.

Authors

Yongqing Ye^{1

2}, Jin Xu¹, Yuhan Han¹

Affiliations

¹ Department of Neurosurgery, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China.
² Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150000, China.

Abstract

The pathogenesis of delayed cerebral edema after intracerebral hemorrhage is still unclear. In this case report, we speculate that the formation of subdural effusion or hemorrhage is associated with delayed cerebral edema. By referring to the treatment plan of chronic subdural hematoma, adding dexamethasone to routine medication, certain therapeutic effect has been achieved. Dexamethasone may maintain the stability of blood-brain barrier by directly increasing the expression of ZO-1, and reduce the neuroinflammatory response caused by NF-κB pathway by upregulating KLF2 expression, ultimately reducing nerve injury through multiple pathways.

Keywords: Blood-brain barrier; Delayed cerebral edema; Dexamethasone; KLF2; Neuroinflammatory.

Publication types

Case Reports