Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review

Leila Peivasteh-Roudsari; Raziyeh Barzegar-Bafrouei; Kurush Aghbolagh Sharifi; Shamimeh Azimisalim; Marziyeh Karami; Solmaz Abedinzadeh; Shabnam Asadinezhad; Behrouz Tajdar-Oranj; Vahideh Mahdavi; Adel Mirza Alizadeh; Parisa Sadighara; Margherita Ferrante; Gea Oliveri Conti; Aynura Aliyeva; Amin Mousavi Khaneghah

doi:10.1016/j.heliyon.2023.e18140

Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review

Heliyon. 2023 Jul 11;9(7):e18140. doi: 10.1016/j.heliyon.2023.e18140. eCollection 2023 Jul.

Authors

Leila Peivasteh-Roudsari¹, Raziyeh Barzegar-Bafrouei², Kurush Aghbolagh Sharifi³, Shamimeh Azimisalim⁴, Marziyeh Karami⁵, Solmaz Abedinzadeh⁶, Shabnam Asadinezhad⁷, Behrouz Tajdar-Oranj¹, Vahideh Mahdavi⁸, Adel Mirza Alizadeh^{9

10}, Parisa Sadighara⁵, Margherita Ferrante¹¹, Gea Oliveri Conti¹¹, Aynura Aliyeva¹², Amin Mousavi Khaneghah^{12

13}

Affiliations

¹ Food and Drug Administration of Iran, Ministry of Health and Medical Education, Tehran, Iran.
² Department of Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
³ Department of Food Science and Technology, Faculty of Agriculture, Urmia University, Urmia, Iran.
⁴ Department of Food Science and Technology, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁵ Food Safety and Hygiene Division, Department of Environmental Health Engineering, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Department of Food Science and Technology, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
⁷ Department of Food Science and Engineering, Faculty of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.
⁸ Iranian Research Institute of Plant Protection, Agricultural Research, Education and Extension Organization (AREEO), P.O. Box 1475744741, Tehran, Iran.
⁹ Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
¹⁰ Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
¹¹ Department of Medical, Surgical and Advanced Technologies "G.F. Ingrassia," Hygiene and Public Health, University of Catania, Via Santa Sofia 87, 95123, Catania, Italy.
¹² Department of Technology of Chemistry, Azerbaijan State Oil and Industry University, Baku, Azerbaijan.
¹³ Department of Fruit and Vegetable Product Technology, Prof. Wacław Dąbrowski Institute of Agricultural and Food Biotechnology - State Research Institute, 36 Rakowiecka St., 02-532, Warsaw, Poland.

Abstract

Endocrine-disrupting chemicals (EDCs) are a growing public health concern worldwide. Consumption of foodstuffs is currently thought to be one of the principal exposure routes to EDCs. However, alternative ways of human exposure are through inhalation of chemicals and dermal contact. These compounds in food products such as canned food, bottled water, dairy products, fish, meat, egg, and vegetables are a ubiquitous concern to the general population. Therefore, understanding EDCs' properties, such as origin, exposure, toxicological impact, and legal aspects are vital to control their release to the environment and food. The present paper provides an overview of the EDCs and their possible disrupting impact on the endocrine system and other organs.

Keywords: Dietary exposure; Endocrine disruption; Food safety; Public health.