Three new sesquiterpenes from roots of Curcuma longa

Jie Zhang; Xiaorui Ma; Wei Wang; Caixia Wu; Ben Ma; Chong Yu; Haifeng Wang

doi:10.1016/j.chmed.2022.11.007

Three new sesquiterpenes from roots of Curcuma longa

Chin Herb Med. 2023 May 22;15(3):470-474. doi: 10.1016/j.chmed.2022.11.007. eCollection 2023 Jul.

Authors

Jie Zhang¹, Xiaorui Ma², Wei Wang¹, Caixia Wu¹, Ben Ma¹, Chong Yu¹, Haifeng Wang¹

Affiliations

¹ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
² Sinopharm Tongmei General Hospital, Datong 037001, China.

Abstract

Objective: To study the chemical constituents from the roots of Curcuma longa.

Methods: The structures of the compounds were elucidated based on extensive spectral analysis, including 1D and 2D NMR, MS, UV, and CD analysis.

Results: Two new sesquiterpene compounds (1S,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (1), (1R,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (2), and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one (3) together with three known compounds ar-turmerone (4), 2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (5) and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (6) were isolated from C. longa root extract with 95% ethanol.

Conclusion: In the study, three new compounds were isolated from C. longa, and their absolute configurations were determined.

Keywords: Curcuma longa L.; NMR; chemical composition; curcumin; sesquiterpenes.