Multimodal management of tenosynovial giant cell tumors (TGCT) in the landscape of new druggable targets

Abstract

Tenosynovial giant cell tumor (TGCT) is a rare, benign, locally aggressive synovial based neoplastic process that can result in functional debilitation and end-stage arthrtitis. Although surgical resection is the primary treatment modality, novel systemic therapies are emerging as part of the multimodal armamentarium for patients with unresectable or complex disease burden. This review discusses the pathogenesis of TGCT, potential druggable targets and therapeutic approaches. It also evaluates the safety and efficacy of different systemic therapies.

Keywords: CSF1; CSF1R; colony-stimulating factor 1; colony-stimulating factor 1 receptor; drug development; drug targets; systemic therapy; tenosynovial giant cell tumor.