Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women

Courtney E Johnson; Anthony J Alberg; Elisa V Bandera; Lauren C Peres; Maxwell Akonde; Lindsay J Collin; Michele L Cote; Theresa A Hastert; James R Hébert; Edward S Peters; Bonnie Qin; Paul Terry; Ann G Schwartz; Melissa Bondy; Michael P Epstein; Hannah B Mandle; Jeffrey R Marks; Andrew B Lawson; Joellen M Schildkraut

doi:10.1038/s41416-023-02385-w

Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women

Br J Cancer. 2023 Oct;129(7):1119-1125. doi: 10.1038/s41416-023-02385-w. Epub 2023 Aug 3.

Authors

Courtney E Johnson¹, Anthony J Alberg², Elisa V Bandera³, Lauren C Peres⁴, Maxwell Akonde², Lindsay J Collin⁵, Michele L Cote⁶, Theresa A Hastert⁷, James R Hébert², Edward S Peters⁸, Bonnie Qin³, Paul Terry⁹, Ann G Schwartz¹⁰, Melissa Bondy¹¹, Michael P Epstein¹², Hannah B Mandle¹, Jeffrey R Marks¹³, Andrew B Lawson^{14

15}, Joellen M Schildkraut¹⁶

Affiliations

¹ Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
² Department of Epidemiology and Biostatistics, University of South Carolina Arnold School of Public Health, Columbia, SC, USA.
³ Cancer and Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
⁴ Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
⁵ Department of Population Health Sciences, University of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA.
⁶ Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Bloomington, IN, USA.
⁷ Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
⁸ Department of Epidemiology, University of Nebraska Medical Center College of Public Health, Omaha, NE, USA.
⁹ Department of Medicine, University of Tennessee Medical Center-Knoxville, Knoxville, TN, USA.
¹⁰ Department of Oncology, Wayne State University School of Medicine Karmanos Cancer Institute, Detroit, MI, USA.
¹¹ Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
¹² Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
¹³ Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
¹⁴ Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
¹⁵ Usher Institute, School of Medicine, University of Edinburgh, Edinburgh, Scotland.
¹⁶ Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA. joellen.m.schildkraut@emory.edu.

PMID: 37537254
PMCID: PMC10539498 (available on 2024-08-03)
DOI: 10.1038/s41416-023-02385-w

Abstract

Background: An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival.

Methods: The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DII^TM), were evaluated.

Results: A dose-response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01-1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02-1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16-2.06).

Conclusion: Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women.

Publication types

Multicenter Study
Research Support, N.I.H., Extramural

MeSH terms

Carcinoma, Ovarian Epithelial / complications
Carcinoma, Ovarian Epithelial / epidemiology
Cohort Studies
Diet
Female
Humans
Inflammation* / complications
Inflammation* / epidemiology
Ovarian Neoplasms*
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding