Inflammatory Pseudotumor of the Liver

Donghai Wang; Joseph Misdraji

doi:10.1016/j.path.2023.04.010

Inflammatory Pseudotumor of the Liver

Surg Pathol Clin. 2023 Sep;16(3):565-580. doi: 10.1016/j.path.2023.04.010. Epub 2023 May 31.

Authors

Donghai Wang¹, Joseph Misdraji²

Affiliations

¹ Department of Pathology, New York University Grossman School of Medicine, NYU Langone Health, 560 First Avenue TH-483, New York, NY 10016, USA.
² Department of Pathology, Yale School of Medicine, Yale New Haven Hospital, 20 York Street EP2-611, New Haven, CT 06510, USA. Electronic address: joseph.misdraji@yale.edu.

PMID: 37536889
DOI: 10.1016/j.path.2023.04.010

Abstract

Hepatic inflammatory pseudotumor (IPT) describes a mass lesion composed of fibroblasts or myofibroblasts with a dense inflammatory infiltrate comprising lymphocyte, plasma cells, and histiocytes. These lesions are presumed to be an exuberant response to an infectious organism, although in most cases the causative agent is unknown. In specific circumstances, pathologists should consider ancillary techniques to exclude specific infections, such as mycobacteria, Candida, or syphilis. IgG4-related disease may cause a plasma-cell rich IPT. Finally, true neoplasms can mimic IPTs and must be excluded with appropriate ancillary studies, including inflammatory myofibroblastic tumor, follicular dendritic cell tumor, inflammatory angiomyolipoma, Hodgkin lymphoma, and inflammatory hepatocellular carcinoma.

Keywords: Abscess; Follicular dendritic cell tumor; Hodgkin lymphoma; IgG4-related disease; Inflammatory myofibroblastic tumor; Inflammatory pseudotumor; Liver; Syphilis.

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular* / diagnosis
Granuloma, Plasma Cell* / diagnosis
Granuloma, Plasma Cell* / pathology
Hodgkin Disease*
Humans
Liver Neoplasms* / diagnosis