Parenteral Nutrition in the Neonatal Intensive Care Unit: Intravenous Lipid Emulsions

Alvin P Chan; Sara Rostas; Samantha Rogers; Camilia R Martin; Kara L Calkins

doi:10.1016/j.clp.2023.04.012

Parenteral Nutrition in the Neonatal Intensive Care Unit: Intravenous Lipid Emulsions

Clin Perinatol. 2023 Sep;50(3):575-589. doi: 10.1016/j.clp.2023.04.012. Epub 2023 Jun 1.

Authors

Alvin P Chan¹, Sara Rostas², Samantha Rogers³, Camilia R Martin⁴, Kara L Calkins⁵

Affiliations

¹ Division of Gastroenterology, Department of Pediatrics, David Geffen School of Medicine UCLA, 10833 Le Conte Avenue, MDCC 12-383, Los Angeles, CA 90095, USA.
² New York-Presbyterian Department of Pharmacy, New York-Presbyterian Hospital/Komansky Children's Hospital, 1283 York Avenue, FL15, New York, NY 10065, USA.
³ New York-Presbyterian Food & Nutrition Services, New York-Presbyterian Hospital/Weill Cornell Medical Center, 1283 York Avenue, FL15, New York, NY 10065, USA.
⁴ Division of Neonatology, Department of Pediatrics, Weill Cornell Medicine, 1283 York Avenue, FL15, New York, NY 10065, USA.
⁵ Division of Neonatology & Developmental Biology, Department of Pediatrics, Neonatal Research Center of the UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA, 1088 Le Conte Avenue, Room B2-375 MDCC, Los Angeles, CA 90095, USA. Electronic address: KCalkins@mednet.ucla.edu.

PMID: 37536765
DOI: 10.1016/j.clp.2023.04.012

Abstract

Intravenous lipid emulsions (ILEs) are a source of nonprotein calories and fatty acids and help promote growth in preterm infants and infants with intestinal failure. An ILE dose and oil source determines its fatty acid, phytosterol, and vitamin E delivery. These factors play a role in the infant's risk for essential fatty acid deficiency and cholestasis, and help modulate inflammation, immunity, and organ development. This article reviews different ILEs and their constituents and their relationship with neonatal health.

Keywords: Fatty acids; Intestinal failure–associated liver disease; Lipids; Neonates; Parenteral nutrition; Premature.

Publication types

Review

MeSH terms

Cholestasis*
Fat Emulsions, Intravenous* / therapeutic use
Fish Oils
Humans
Infant
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Parenteral Nutrition
Soybean Oil

Substances

Fat Emulsions, Intravenous
Fish Oils
Soybean Oil